GST-RNF4
RING-finger 4 (RNF4), also known as Snurf, is an E3 ubiquitin ligase. RNF4 is composed of four SUMO interaction motifs (SIMs) at the N-terminal and a RING domain at the C-terminal. The SIM domains prefer binding polySUMO chains; RNF4 functions to ubiquitinate polysumolyated proteins including promyelocytic leukaemia (PML), which target them for proteasomal degradation.
Product Name:
GST-RNF4
>Also Known As:
SLX5; SNURF; RES4-26
>Catalog No.:
K1100
>Size:
50 µg
>Molecular Weight:
21.3 kDa
>Species:
Human
>Source:
Bacterial recombinant
>Stock:
20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol
>Concentration:
See tube label
>Quality Assurance:
~90% by SDS-PAGE, see datasheet for gel image
>Storage:
Store at -80°C; avoid multiple freeze-thaw cycles
>PDF Data Sheet:
PDF Datasheet， MSDS
>NCBI RefSeq:
NM_001185009
>Image(s):
(Click image to enlarge)
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Coomassie-stained SDS-PAGE Lane 1: Molecular weight markers Lane 2: 5 µg purified GST-RNF4 |
>Shipping Method:
Dry ice shipping
>References:
1. Chiariotti L, et al. (1998) Genomics 47(2), 258 – 265.
2. Fedele M, et al. (2000) J Biol Chem 275(11), 7894 – 7901.
3. Hunter T, Sun H (2008) Ernst Schering Found Sump Proc (1), 1 – 16.
4. Tatham MH, et al. (2008) Nat Cell BIol 10(5), 538 – 546.
5. Bruderer R, et al. (2011) EMBO Rep 12(2), 142 – 148. PF-04418948 18474844
