6xHis-SENP1 (catalytic domain)
SUMO1-3 (small ubiquitin-related modifiers) are ubiquitin-like proteins that can be conjugated to substrate proteins using a cascade of enzymatic reactions. Protein sumoylation can be reversed by the sentrin-specific (SUMO is also named sentrin) proteases (SENPs). In human cells, SENPs have six members including SENP1, SENP2, SENP3, SENP5, SENP6 and SENP7. SENPs mostly reside in the nucleus. They function to generate mature SUMO1-3 from the SUMO precursors and attenuate signals mediated by sumoylation. The SENP1 catalytic domain comprises amino acid from 419 to 644.
Product Name:
6xHis-SENP1 (catalytic domain)
>Also Known As:
SuPr-2
>Catalog No.:
H9120
>Size:
25 µg
>Molecular Weight:
26.9 kDa
>Species:
Human
>Source:
Bacterial recombinant
>Stock:
20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol
>Concentration:
See tube label
>Quality Assurance:
> 95% by SDS-PAGE, see datasheet for gel image
>Storage:
Store at -80°C; avoid multiple freeze-thaw cycles
>PDF Data Sheet:
PDF Datasheet， MSDS
>NCBI RefSeq:
NM_001267594.1
>Image(s):
(Click image to enlarge)
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Coomassie-stained SDS-PAGE Lane 1: Molecular weight markers Lane 2: 5 µg purified 6xHis-SENP1 (catalytic domain) |
>Shipping Method:
Dry ice shipping
>References:
1. Hickey CM, et al. (2012) Nat Rev Mol Cell Biol. 13(12):755-66.
2. Yeh ET, et al. (2009) J Biol Chem. 284(13):8223-7. LY2606368 18469240
