6xHis-Usp14
Usp14 is one of the deubiquitinating enzymes of the human 26S proteasome. Usp14 belongs to the Ub-specific proteases family. Usp14 catalyzes Ub chain trimming that shortens a polyUb chain from the distal end of the Ub chain. Usp14 was found to play an essential role in maintaining the protein levels of monomeric Ub in cells. Interestingly, Usp14 was also found to inhibit proteasomal degradation independent of its deubiquitinating activity.
Product Name:
6xHis-Usp14
>Also Known As:
TGT;Usp14
>Catalog No.:
A3710
>Size:
25 µg
>Molecular Weight:
56.1 kDa
>Species:
Human
>Source:
Bacterial recombinant
>Stock:
20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol
>Concentration:
See tube label
>Quality Assurance:
~90% by SDS-PAGE, see datasheet for gel image
>Storage:
Store at -80°C; avoid multiple freeze-thaw cycles
>PDF Data Sheet:
PDF Datasheet， MSDS
>NCBI RefSeq:
NM_005151
>Image(s):
(Click image to enlarge)
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Coomassie-stained SDS-PAGE Lane 1: Molecular weight markers Lane 2: 5 µg purified 6xHis-Usp14 |
>Shipping Method:
Dry ice shipping
>References:
1. Lam YA, et al. (1997) Nature 385(6618), 737 – 740.
2. Koulich E, et al. (2007) Mol Biol Cell, 19(3) 1072 – 1082.
3. Lee BH, et al. (2010) Nature 467, 179 – 184. PKC412 18468477
