Lure assessment doi:10.1371/journal.pone.0146745.tFig 2. Diagram of the total enrolled patients. (A) acute Pinometostat site deterioration with chronic liver disease (enrolled patients) (N = 1470); (B) CLD patients without prior history of decompensation (N = 1021); (C) cirrhotic patients regardless of prior history of decompensation (N = 1352); (D) ACLF development Vercirnon msds according to the AARC definition (N = 140); (E) ACLF development according to the Grazoprevir molecular weight CLIF-C definition (N = 274); (F) ACLF development according to the AARC and CLIF-C definitions (N = 74). Abbreviations: CLD, chronic liver disease; ACLF, acute-on-chronic liver failure; AARC, Asian Pacific Association for the Study of the Liver ACLF Research Consortium; CLIF-C, Chronic liver QVD-OPH web failure consortium doi:10.1371/journal.pone.0146745.gPLOS ONE | DOI:10.1371/journal.pone.0146745 January 20,7 /Acute-on-Chronic Liver FailureFig 3. Twenty-eight- and 90-day mortality of patients with ACLF. (A) AARC definition, (B) CLIF-C definition. *One hundred sixty-three patients were lost to follow up. Abbreviations: AARC, Asian Pacific Association for the Study of the Liver ACLF Research Consortium; CLIF-C, Chronic liver failure consortium doi:10.1371/journal.pone.0146745.gsignificantly lower 28-day and 90-day survival rates than those who only met the AARC definition (68.0 vs. 93.9 , P < 0.001; 55.1 vs. 92.4 , P < 0.001). Patients with ACLF at or within 28 days of admission showed a significantly lower 90-day cumulative survival rate compared to those without ACLF (according to the AARC definition: 67.8 or 55.4 vs. 90.5 , P < 0.001; according to the CLIF-C definition: 58.8 or 29.1 vs. 96.5 , P < 0.001) (Fig 5). The cumulative survival rate of those who developed ACLF after admission was significantly lower than that of those who had ACLF at admission according to the CLIF-C definition (P < 0.001), but not according to the AARC definition (P = 0.154).Fig 4. Kaplan-Meier survival curves according to the definition of ACLF. (A) 28-day survival and (B) 90-day survival. Abbreviations: ACLF, Acute-onchronic liver failure; AARC, Asian Pacific Association for the Study of the Liver ACLF wcs.1183 Research Consortium; CLIF-C, Chronic Liver Failure Consortium. doi:10.1371/journal.pone.0146745.gPLOS ONE | DOI:10.1371/journal.pone.0146745 January 20,8 /Acute-on-Chronic Liver FailureFig 5. Kaplan-Meier survival curves according to the time of ACLF development. (A) AARC definition, (B) CLIF-C definition. Abbreviations: ACLF, Acute-on-chronic liver failure; AARC, Asian Pacific Association for the Study of the Liver ACLF Research Consortium; CLIF-C, Chronic liver failure consortium doi:10.1371/journal.pone.0146745.gDiscordant baseline characteristics between patients with ACLF defined by the AARC and CLIF-CBaseline characteristics of patients with ACLF who met only the AARC definition, only the CLIF-C definition, or both j.jebo.2013.04.005 definitions are shown in Table 2. The CLIF-C only group were older, had HE and GIB more frequently compared to the AARC only group. In contrast, ascites was more frequent as a cause of acute deterioration in the AARC only group. The CLIF-C only group had more bacterial infections and GIB, but less active alcoholism and toxic material use as the precipitating event than the AARC only group. Mean blood pressure was lower in the CLIF-C only group. In laboratory findings, the CLIF-C only group showed higher creatinine level and lower hemoglobin, and gamma-glutamyl transferase levels than the AARC only group. Patients who only.Lure assessment doi:10.1371/journal.pone.0146745.tFig 2. Diagram of the total enrolled patients. (A) acute deterioration with chronic liver disease (enrolled patients) (N = 1470); (B) CLD patients without prior history of decompensation (N = 1021); (C) cirrhotic patients regardless of prior history of decompensation (N = 1352); (D) ACLF development according to the AARC definition (N = 140); (E) ACLF development according to the CLIF-C definition (N = 274); (F) ACLF development according to the AARC and CLIF-C definitions (N = 74). Abbreviations: CLD, chronic liver disease; ACLF, acute-on-chronic liver failure; AARC, Asian Pacific Association for the Study of the Liver ACLF Research Consortium; CLIF-C, Chronic liver failure consortium doi:10.1371/journal.pone.0146745.gPLOS ONE | DOI:10.1371/journal.pone.0146745 January 20,7 /Acute-on-Chronic Liver FailureFig 3. Twenty-eight- and 90-day mortality of patients with ACLF. (A) AARC definition, (B) CLIF-C definition. *One hundred sixty-three patients were lost to follow up. Abbreviations: AARC, Asian Pacific Association for the Study of the Liver ACLF Research Consortium; CLIF-C, Chronic liver failure consortium doi:10.1371/journal.pone.0146745.gsignificantly lower 28-day and 90-day survival rates than those who only met the AARC definition (68.0 vs. 93.9 , P < 0.001; 55.1 vs. 92.4 , P < 0.001). Patients with ACLF at or within 28 days of admission showed a significantly lower 90-day cumulative survival rate compared to those without ACLF (according to the AARC definition: 67.8 or 55.4 vs. 90.5 , P < 0.001; according to the CLIF-C definition: 58.8 or 29.1 vs. 96.5 , P < 0.001) (Fig 5). The cumulative survival rate of those who developed ACLF after admission was significantly lower than that of those who had ACLF at admission according to the CLIF-C definition (P < 0.001), but not according to the AARC definition (P = 0.154).Fig 4. Kaplan-Meier survival curves according to the definition of ACLF. (A) 28-day survival and (B) 90-day survival. Abbreviations: ACLF, Acute-onchronic liver failure; AARC, Asian Pacific Association for the Study of the Liver ACLF wcs.1183 Research Consortium; CLIF-C, Chronic Liver Failure Consortium. doi:10.1371/journal.pone.0146745.gPLOS ONE | DOI:10.1371/journal.pone.0146745 January 20,8 /Acute-on-Chronic Liver FailureFig 5. Kaplan-Meier survival curves according to the time of ACLF development. (A) AARC definition, (B) CLIF-C definition. Abbreviations: ACLF, Acute-on-chronic liver failure; AARC, Asian Pacific Association for the Study of the Liver ACLF Research Consortium; CLIF-C, Chronic liver failure consortium doi:10.1371/journal.pone.0146745.gDiscordant baseline characteristics between patients with ACLF defined by the AARC and CLIF-CBaseline characteristics of patients with ACLF who met only the AARC definition, only the CLIF-C definition, or both j.jebo.2013.04.005 definitions are shown in Table 2. The CLIF-C only group were older, had HE and GIB more frequently compared to the AARC only group. In contrast, ascites was more frequent as a cause of acute deterioration in the AARC only group. The CLIF-C only group had more bacterial infections and GIB, but less active alcoholism and toxic material use as the precipitating event than the AARC only group. Mean blood pressure was lower in the CLIF-C only group. In laboratory findings, the CLIF-C only group showed higher creatinine level and lower hemoglobin, and gamma-glutamyl transferase levels than the AARC only group. Patients who only.Lure assessment doi:10.1371/journal.pone.0146745.tFig 2. Diagram of the total enrolled patients. (A) acute deterioration with chronic liver disease (enrolled patients) (N = 1470); (B) CLD patients without prior history of decompensation (N = 1021); (C) cirrhotic patients regardless of prior history of decompensation (N = 1352); (D) ACLF development according to the AARC definition (N = 140); (E) ACLF development according to the CLIF-C definition (N = 274); (F) ACLF development according to the AARC and CLIF-C definitions (N = 74). Abbreviations: CLD, chronic liver disease; ACLF, acute-on-chronic liver failure; AARC, Asian Pacific Association for the Study of the Liver ACLF Research Consortium; CLIF-C, Chronic liver failure consortium doi:10.1371/journal.pone.0146745.gPLOS ONE | DOI:10.1371/journal.pone.0146745 January 20,7 /Acute-on-Chronic Liver FailureFig 3. Twenty-eight- and 90-day mortality of patients with ACLF. (A) AARC definition, (B) CLIF-C definition. *One hundred sixty-three patients were lost to follow up. Abbreviations: AARC, Asian Pacific Association for the Study of the Liver ACLF Research Consortium; CLIF-C, Chronic liver failure consortium doi:10.1371/journal.pone.0146745.gsignificantly lower 28-day and 90-day survival rates than those who only met the AARC definition (68.0 vs. 93.9 , P < 0.001; 55.1 vs. 92.4 , P < 0.001). Patients with ACLF at or within 28 days of admission showed a significantly lower 90-day cumulative survival rate compared to those without ACLF (according to the AARC definition: 67.8 or 55.4 vs. 90.5 , P < 0.001; according to the CLIF-C definition: 58.8 or 29.1 vs. 96.5 , P < 0.001) (Fig 5). The cumulative survival rate of those who developed ACLF after admission was significantly lower than that of those who had ACLF at admission according to the CLIF-C definition (P < 0.001), but not according to the AARC definition (P = 0.154).Fig 4. Kaplan-Meier survival curves according to the definition of ACLF. (A) 28-day survival and (B) 90-day survival. Abbreviations: ACLF, Acute-onchronic liver failure; AARC, Asian Pacific Association for the Study of the Liver ACLF wcs.1183 Research Consortium; CLIF-C, Chronic Liver Failure Consortium. doi:10.1371/journal.pone.0146745.gPLOS ONE | DOI:10.1371/journal.pone.0146745 January 20,8 /Acute-on-Chronic Liver FailureFig 5. Kaplan-Meier survival curves according to the time of ACLF development. (A) AARC definition, (B) CLIF-C definition. Abbreviations: ACLF, Acute-on-chronic liver failure; AARC, Asian Pacific Association for the Study of the Liver ACLF Research Consortium; CLIF-C, Chronic liver failure consortium doi:10.1371/journal.pone.0146745.gDiscordant baseline characteristics between patients with ACLF defined by the AARC and CLIF-CBaseline characteristics of patients with ACLF who met only the AARC definition, only the CLIF-C definition, or both j.jebo.2013.04.005 definitions are shown in Table 2. The CLIF-C only group were older, had HE and GIB more frequently compared to the AARC only group. In contrast, ascites was more frequent as a cause of acute deterioration in the AARC only group. The CLIF-C only group had more bacterial infections and GIB, but less active alcoholism and toxic material use as the precipitating event than the AARC only group. Mean blood pressure was lower in the CLIF-C only group. In laboratory findings, the CLIF-C only group showed higher creatinine level and lower hemoglobin, and gamma-glutamyl transferase levels than the AARC only group. Patients who only.Lure assessment doi:10.1371/journal.pone.0146745.tFig 2. Diagram of the total enrolled patients. (A) acute deterioration with chronic liver disease (enrolled patients) (N = 1470); (B) CLD patients without prior history of decompensation (N = 1021); (C) cirrhotic patients regardless of prior history of decompensation (N = 1352); (D) ACLF development according to the AARC definition (N = 140); (E) ACLF development according to the CLIF-C definition (N = 274); (F) ACLF development according to the AARC and CLIF-C definitions (N = 74). Abbreviations: CLD, chronic liver disease; ACLF, acute-on-chronic liver failure; AARC, Asian Pacific Association for the Study of the Liver ACLF Research Consortium; CLIF-C, Chronic liver failure consortium doi:10.1371/journal.pone.0146745.gPLOS ONE | DOI:10.1371/journal.pone.0146745 January 20,7 /Acute-on-Chronic Liver FailureFig 3. Twenty-eight- and 90-day mortality of patients with ACLF. (A) AARC definition, (B) CLIF-C definition. *One hundred sixty-three patients were lost to follow up. Abbreviations: AARC, Asian Pacific Association for the Study of the Liver ACLF Research Consortium; CLIF-C, Chronic liver failure consortium doi:10.1371/journal.pone.0146745.gsignificantly lower 28-day and 90-day survival rates than those who only met the AARC definition (68.0 vs. 93.9 , P < 0.001; 55.1 vs. 92.4 , P < 0.001). Patients with ACLF at or within 28 days of admission showed a significantly lower 90-day cumulative survival rate compared to those without ACLF (according to the AARC definition: 67.8 or 55.4 vs. 90.5 , P < 0.001; according to the CLIF-C definition: 58.8 or 29.1 vs. 96.5 , P < 0.001) (Fig 5). The cumulative survival rate of those who developed ACLF after admission was significantly lower than that of those who had ACLF at admission according to the CLIF-C definition (P < 0.001), but not according to the AARC definition (P = 0.154).Fig 4. Kaplan-Meier survival curves according to the definition of ACLF. (A) 28-day survival and (B) 90-day survival. Abbreviations: ACLF, Acute-onchronic liver failure; AARC, Asian Pacific Association for the Study of the Liver ACLF wcs.1183 Research Consortium; CLIF-C, Chronic Liver Failure Consortium. doi:10.1371/journal.pone.0146745.gPLOS ONE | DOI:10.1371/journal.pone.0146745 January 20,8 /Acute-on-Chronic Liver FailureFig 5. Kaplan-Meier survival curves according to the time of ACLF development. (A) AARC definition, (B) CLIF-C definition. Abbreviations: ACLF, Acute-on-chronic liver failure; AARC, Asian Pacific Association for the Study of the Liver ACLF Research Consortium; CLIF-C, Chronic liver failure consortium doi:10.1371/journal.pone.0146745.gDiscordant baseline characteristics between patients with ACLF defined by the AARC and CLIF-CBaseline characteristics of patients with ACLF who met only the AARC definition, only the CLIF-C definition, or both j.jebo.2013.04.005 definitions are shown in Table 2. The CLIF-C only group were older, had HE and GIB more frequently compared to the AARC only group. In contrast, ascites was more frequent as a cause of acute deterioration in the AARC only group. The CLIF-C only group had more bacterial infections and GIB, but less active alcoholism and toxic material use as the precipitating event than the AARC only group. Mean blood pressure was lower in the CLIF-C only group. In laboratory findings, the CLIF-C only group showed higher creatinine level and lower hemoglobin, and gamma-glutamyl transferase levels than the AARC only group. Patients who only.
