Rtality in both colon and rectal cancer patients. It is unclear why there is discrepancy in results between the study of Van de Poll-Franse [34] and the current study. One possible explanation could include the racial differences between the two studies. Additionally, Van de PollFranse [34] reported 
that less aggressive treatment regimen was adopted for cancer patients with DM compared with patients who did not have DM. Although rectal cancer patients with DM wereRectal Cancer Age, Gender No. at Adjusted HR (95 Multivariate HR risk CI) (95 CI) No. of LY-2409021 site events Colon Cancer Age, Gender No. at Adjusted HR risk (95 CI) Multivariate HR (95 CI) No. at Age, GenderMultivariate HR (95 No. of risk Adjusted HR (95 CI)CI) events 3614 517 1.09 (0.91?.30) 1.17 (0.96?.42) 62 229 0.89 (0.68?.16) 0.96 (0.73?.27) 1.0 (Ref) 1.0 (Ref) 508 1719 1.0 (Ref) 1.0 (Ref) 388 79 1895 288 1.0 (Ref) 1.35 (1.05?.72) 1.0 (Ref) 1.46 (1.11?.92) 3614 517 1.13 (0.97?.33) 1.17 (1.00?.37) 81 229 0.94 (0.74?.18) 1.0 (Ref) 1.0 (Ref) 635 1719 1.0 (Ref) 1.0 (Ref) 0.98 (0.76?.25) 492 101 1895 288 1.0 (Ref) 1.38 (1.10?.71) 1.0 (Ref) 1.45 (1.15?.84) 3614 517 1.12 (0.93?.35) 1.11 (0.90?.36) 58 229 1.0 (Ref) 1.0 (Ref) 482 1719 1.0 (Ref) 0.95 (0.72?.25) 1.0 (Ref) 0.96 (0.72?.28) 345 66 1895 288 1.0 (Ref) 1.35 (1.04?.77) 1.0 (Ref) 1.32(0.98?.76) 3614 517 1.04 (0.82?.31) 1.08 (0.86?.37) 39 1.0 (Ref) 1.0 (Ref) 355 1719 229 1.0 (Ref) 0.86 (0.62?.20) 1.0 (Ref) 0.92 (0.65?.31) 241 44 1895 288 1.0 (Ref) 1.27 (0.92?.76) 1.0 (Ref) 1.25 (0.87?.80)Table 2. Impact of diabetes mellitus on overall survival and disease-free survival of stage 1? colorectal cancer patients.Colorectal CancerNo. of eventsOverall survivalNo DMDMDisease-free SurvivalNo DMDMRecurrence Free SurvivalNo DMDMColorectal cancerKDM5A-IN-1 cost specific mortalityNo DMDMSite Specific Effects of DM on Colorectal CancerHR: Hazard Ratio. Multivariable adjustment for BMI, age, sex, family history of colorectal cancer (yes or no), TNM stage (1, 2, 3), Adjuvant therapy (No, Chemotherapy only, Radiation therapy only, Chemotherapy and radiation therapy together) and the year of surgery. doi:10.1371/journal.pone.0055196.tSite Specific Effects of DM on Colorectal CancerTable 3. Impact of DM on outcome of overall survival 1081537 of stage 1 to 3 colon cancer patients according to their BMI, TNM stage, age and site of cancer (proximal vs distal).Non DM DM Risk of overall survival Male No at risk/events MV adjusted (95 CI) Female No at risk/events MV adjusted (95 CI) ^ BMI specific effects of DM BMI ,23 kg/m2 No at risk/events MV adjusted (95 CI) BMI .23 kg/m2 No at risk/events MV adjusted (95 CI) Stage specific effects of DM TNM Stage I/II No at risk/events MV adjusted (95 CI) TNM Stage III No at risk/events MV adjusted (95 CI) Age specific effects of DM Age ,60 years No at risk/events MV adjusted (95 CI) Age 60 years No at risk/events MV adjusted (95 CI) Site Specific effects of DM * Proximal Colon No at risk/events MV adjusted (95 CI) Distal Colon No at risk/events MV adjusted (95 CI) 1073/215 153/37 1.00 (Ref) 1.34 (0.92?.96) 798/170 128/39 918/243 16574785 199/59 977/145 89/20 711/214 108/36 1184/174 180/43 1.00 (Ref) 1.38 (1.05?.81) 828/141 153/36 877/186 109/29 804/154 107/30 1091/234 181/49 1.00 (Ref) 1.45 (1.02?.06)PtrendPinteraction0.038 0.1.00 (Ref) 1.48 (0.96?.30)0.1.00 (Ref) 1.48 (1.06?.05)0.02 0.1.00 (Ref) 1.52 (1.04?.21)0.0.019 0.1.00 (Ref) 1.25 (0.84?.85)0.1.00 (Ref) 2.04 (1.17?.54)0.012 0.1.00 (Ref) 1.43 (1.04?.96)0.1.00 (Ref) 2.08 (1.38?.13).0.0.Rtality in both colon and rectal cancer patients. It is unclear why there is discrepancy in results between the study of Van de Poll-Franse [34] and the current study. One possible explanation could include the racial differences between the two studies. Additionally, Van de PollFranse [34] reported that less aggressive treatment regimen was adopted for cancer patients with DM compared with patients who did not have DM. Although rectal cancer patients with DM wereRectal Cancer Age, Gender No. at Adjusted HR (95 Multivariate HR risk CI) (95 CI) No. of events Colon Cancer Age, Gender No. at Adjusted HR risk (95 CI) Multivariate HR (95 CI) No. at Age, GenderMultivariate HR (95 No. of risk Adjusted HR (95 CI)CI) events 3614 517 1.09 (0.91?.30) 1.17 (0.96?.42) 62 229 0.89 (0.68?.16) 0.96 (0.73?.27) 1.0 (Ref) 1.0 (Ref) 508 1719 1.0 (Ref) 1.0 (Ref) 388 79 1895 288 1.0 (Ref) 1.35 (1.05?.72) 1.0 (Ref) 1.46 (1.11?.92) 3614 517 1.13 (0.97?.33) 1.17 (1.00?.37) 81 229 0.94 (0.74?.18) 1.0 (Ref) 1.0 (Ref) 635 1719 1.0 (Ref) 1.0 (Ref) 0.98 (0.76?.25) 492 101 1895 288 1.0 (Ref) 1.38 (1.10?.71) 1.0 (Ref) 1.45 (1.15?.84) 3614 517 1.12 (0.93?.35) 1.11 (0.90?.36) 58 229 1.0 (Ref) 1.0 (Ref) 482 1719 1.0 (Ref) 0.95 (0.72?.25) 1.0 (Ref) 0.96 (0.72?.28) 345 66 1895 288 1.0 (Ref) 1.35 (1.04?.77) 1.0 (Ref) 1.32(0.98?.76) 3614 517 1.04 (0.82?.31) 1.08 (0.86?.37) 39 1.0 (Ref) 1.0 (Ref) 355 1719 229 1.0 (Ref) 0.86 (0.62?.20) 1.0 (Ref) 0.92 (0.65?.31) 241 44 1895 288 1.0 (Ref) 1.27 (0.92?.76) 1.0 (Ref) 1.25 (0.87?.80)Table 2. Impact of diabetes mellitus on overall survival and disease-free survival of stage 1? colorectal cancer patients.Colorectal CancerNo. of eventsOverall survivalNo DMDMDisease-free SurvivalNo DMDMRecurrence Free SurvivalNo DMDMColorectal cancerspecific mortalityNo DMDMSite Specific Effects of DM on Colorectal CancerHR: Hazard Ratio. Multivariable adjustment for BMI, age, sex, family history of colorectal cancer (yes or no), TNM stage (1, 2, 3), Adjuvant therapy (No, Chemotherapy only, Radiation therapy only, Chemotherapy and radiation therapy together) and the year of surgery. doi:10.1371/journal.pone.0055196.tSite Specific Effects of DM on Colorectal CancerTable 3. Impact of DM on outcome of overall survival 1081537 of stage 1 to 3 colon cancer patients according to their BMI, TNM stage, age and site of cancer (proximal vs distal).Non DM DM Risk of overall survival Male No at risk/events MV adjusted (95 CI) Female No at risk/events MV adjusted (95 CI) ^ BMI specific effects of DM BMI ,23 kg/m2 No at risk/events MV adjusted (95 CI) BMI .23 kg/m2 No at risk/events MV adjusted (95 CI) Stage specific effects of DM TNM Stage I/II 
No at risk/events MV adjusted (95 CI) TNM Stage III No at risk/events MV adjusted (95 CI) Age specific effects of DM Age ,60 years No at risk/events MV adjusted (95 CI) Age 60 years No at risk/events MV adjusted (95 CI) Site Specific effects of DM * Proximal Colon No at risk/events MV adjusted (95 CI) Distal Colon No at risk/events MV adjusted (95 CI) 1073/215 153/37 1.00 (Ref) 1.34 (0.92?.96) 798/170 128/39 918/243 16574785 199/59 977/145 89/20 711/214 108/36 1184/174 180/43 1.00 (Ref) 1.38 (1.05?.81) 828/141 153/36 877/186 109/29 804/154 107/30 1091/234 181/49 1.00 (Ref) 1.45 (1.02?.06)PtrendPinteraction0.038 0.1.00 (Ref) 1.48 (0.96?.30)0.1.00 (Ref) 1.48 (1.06?.05)0.02 0.1.00 (Ref) 1.52 (1.04?.21)0.0.019 0.1.00 (Ref) 1.25 (0.84?.85)0.1.00 (Ref) 2.04 (1.17?.54)0.012 0.1.00 (Ref) 1.43 (1.04?.96)0.1.00 (Ref) 2.08 (1.38?.13).0.0.
