Product Name :
Rabbit anti-Synaptophysin Polyclonal Antibody
Synonym :
Major synaptic vesicle protein p38; SYP
Host :
Rabbit
Species Reactivity:
Human, Mouse, Rat
Specificity :
Synaptophysin antibody detects endogenous levels of total Synaptophysin.
Predicted Reactivity:
Pig, Sheep, Bovine, Horse
Applications :
WB: 1:500~1:3000, IHC: 1:50~1:200, IF 1:200, ELISA(peptide) 1:20000-1:40000
Immunogen:
A synthesized peptide derived from Human SYP(Accession P08247), corresponding to amino acid residues A121-D142.
Concentration :
1mg/ml
Purification :
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality:
Monoclonal antibody
Storage Temp.:
Store at -20 ° C for one yearAvoid repeated freeze/that cycles
Research areas :
Background :
Synaptophysin, also known as the major synaptic vesicle protein p38, is a protein that in humans is encoded by the SYP gene. The protein is a synaptic vesicle glycoprotein with four transmembrane domains weighing 38kDa. It is present in neuroendocrine cells and in virtually all neurons in the brain and spinal cord that participate in synaptic transmission. It acts as a marker for neuroendocrine tumors, and its ubiquity at the synapse has led to the use of synaptophysin immunostaining for quantification of synapses.
UniProt :
P08247
Additional information:
Product Details FAQ Citations(0) Video Pictures Documents |Overview |Description SYP Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity. Belongs to the synaptophysin/synaptobrevin family. Homohexamer or homotetramer. Note: This description may include information from UniProtKB. |Synonym Major synaptic vesicle protein p38; SYP |Host Rabbit |Specificity Synaptophysin antibody detects endogenous levels of total Synaptophysin. |Species Reactivity Human, Mouse, Rat |Predicted Reactivity Pig, Sheep, Bovine, Horse |Applications WB: 1:500~1:3000, IHC: 1:50~1:200, IF 1:200, ELISA(peptide) 1:20000-1:40000 |Immunogen A synthesized peptide derived from Human SYP(Accession P08247), corresponding to amino acid residues A121-D142. |Properties |Form liquid |Concentration 1mg/ml |Purification The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin . |Clonality Monoclonal antibody |Clone 137-21 |Storage Temp. Store at -20 ° C for one yearAvoid repeated freeze/that cycles |Storage Buffer Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |Target |Background Synaptophysin, also known as the major synaptic vesicle protein p38, is a protein that in humans is encoded by the SYP gene. The protein is a synaptic vesicle glycoprotein with four transmembrane domains weighing 38kDa. It is present in neuroendocrine cells and in virtually all neurons in the brain and spinal cord that participate in synaptic transmission. It acts as a marker for neuroendocrine tumors, and its ubiquity at the synapse has led to the use of synaptophysin immunostaining for quantification of synapses. |tissuespecificity Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype. |Post-translational modifications Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation. |Cellular localization Plasma Membrane; |UniProt P08247 | Western blot analysis on LOVO cell lysate using Synaptophysin Antibody |Tips:This product is for research use only. Not for use in diagnostic prodcedures.
Rabbit anti-Synaptophysin Recombiant Monoclonal Antibody(137-21)
Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.Related websites: https://www.medchemexpress.com/antibodies.html
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