Product Name :
Patamostat mesylate
Description:
Patamostat (E-3123) mesylate is a potent protease inhibitor. Patamostat mesylate potently inhibits trypsin, plasmin and thrombin with IC50s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat mesylate may possess suppressing effects on pathogenesis and development of acute pancreatitis.
CAS:
114568-32-0
Molecular Weight:
508.57
Formula:
C21H24N4O7S2
Chemical Name:
4-[2-(2,5-dioxopyrrolidin-1-yl)ethyl]sulfanylphenyl 4-[(diaminomethylidene)amino]benzoate; methanesulfonic acid
Smiles :
CS(O)(=O)=O.NC(N)=NC1C=CC(=CC=1)C(=O)OC1C=CC(=CC=1)SCCN1C(=O)CCC1=O
InChiKey:
HTSFLDCSCNSKJW-UHFFFAOYSA-N
InChi :
InChI=1S/C20H20N4O4S.CH4O3S/c21-20(22)23-14-3-1-13(2-4-14)19(27)28-15-5-7-16(8-6-15)29-12-11-24-17(25)9-10-18(24)26;1-5(2,3)4/h1-8H,9-12H2,(H4,21,22,23);1H3,(H,2,3,4)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Vandetanib Autophagy
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Patamostat (E-3123) mesylate is a potent protease inhibitor. Patamostat mesylate potently inhibits trypsin, plasmin and thrombin with IC50s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat mesylate may possess suppressing effects on pathogenesis and development of acute pancreatitis.|Product information|CAS Number: 114568-32-0|Molecular Weight: 508.57|Formula: C21H24N4O7S2|Chemical Name: 4-[2-(2,5-dioxopyrrolidin-1-yl)ethyl]sulfanylphenyl 4-[(diaminomethylidene)amino]benzoate; methanesulfonic acid|Smiles: CS(O)(=O)=O.NC(N)=NC1C=CC(=CC=1)C(=O)OC1C=CC(=CC=1)SCCN1C(=O)CCC1=O|InChiKey: HTSFLDCSCNSKJW-UHFFFAOYSA-N|InChi: InChI=1S/C20H20N4O4S.CH4O3S/c21-20(22)23-14-3-1-13(2-4-14)19(27)28-15-5-7-16(8-6-15)29-12-11-24-17(25)9-10-18(24)26;1-5(2,3)4/h1-8H,9-12H2,(H4,21,22,23);1H3,(H,2,3,4)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.LM10 Autophagy |Shelf Life: ≥12 months if stored properly.PMID:31643211 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Patamostat mesylate (intravenous infusion) at 0.03-0.3 mg/kg in rats or at 0.3-3.0 mg/kg in rabbits reduces mortality after the induction of pancreatitis in a dose-dependent manner. Patamostat mesylate (1.0-3.0 mg/kg; intravenous infusion) reduces the increases of serum trypsin and lipase activities in dogs with pancreatitis. Patamostat mesylate (2 mg/kg per h; continuous infusion) improves almost all parameters, including mortality rate, serum and ascitic fluid amylase levels, plasma endotoxin and serum FDP levels, and distribution of lysosomal enzyme in male Wistar rats.|Products are for research use only. Not for human use.|
