Name:
NGFR/TNFRSF16 Protein
Synonyms:
Gp80-LNGFR，NGF Receptor，Low Affinity Neurotrophin Receptor P75NTR，Nerve Growth Factor Receptor (TNFR Superfamily， Member 16)，NGFR，TNFR Superfamily， Member 16，Tumor Necrosis Factor Receptor Superfamily Member 16，CD271，CD271 Antigen，Low Affinity Nerve Growth Factor Receptor，Low-Affinity Nerve Growth Factor Receptor，P75 ICD，Nerve Growth Factor Receptor，P75(NTR)，TNFRSF16，P75NTR
Species Name:
Human
Label Name:
null
Marker Name:
Unconjugated
Accession:
P08138-1
Gene Id:
Lys29-Asn250KEACPTGLYTHSGECCKACNLGEGVAQPCGANQTVCEPCLDSVTFSDVVSATEPCKPCTECVGLQSMSAPCVEADDAVCRCAYGYYQDETTGRCEACRVCEAGSGLVFSCQDKQNTVCEECPDGTYSDEANHVDPCLPCTVCEDTERQLRECTRWADAECEEIPGRWITRSTPPEGSDSTAPSTQEPEAPPEQDLIASTVAGVVTTVMGSSQPVVTRGTTDNGGGSGGGSPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
Molecular Weight:
70-90kDa (Reducing)
Purity:
＞95% by SDS-PAGE & >90% by RP-HPLC
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, PH7.4, 5% trehalose
Quality Statement:
p75 neurotrophin receptor, also named low affinity NGF receptor (NGF R), is a type I transmembrane protein that belongs to the tumor necrosis factor receptor family. The extracellular region contains four cysteine-rich domains and binds NGF, BDNF, NT-3 and NT-4 approximately equally with low affinity. The cytoplasmic region contains a subtype 2 death domain. NGF R expression has been shown to occur widely during development and in the adult. Expression has been detected in both neuronal and non-neuronal cells. NGF R was originally reported to function as a positive regulator of TrkA activity. NGF R has also been shown to signal by itself. Depending on its cellular environment, NGF R has now been shown to regulate cell migration, gene expression and to mediate apoptosis. Recombinant NGF R/Fc chimera binds NGF with high affinity and is a potent NGF antagonist. Naturally occurring truncated NGF R containing the extracellular domain and lacking the transmembrane or intracellular domain has been detected in vivo in urine, plasma and in amniotic fluid of humans and rats.
Reference:
1.Barker, P.A. and R.A. Murphy (1992) Molecular and Cellular Biochemistry 110:1.2.Bamji, A.X. et al. (1998) J. Cell Biol. 140:911.3.Feinstein, E. et al. (1995) Trends Biochem. Sci. 20:342.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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