IL-18Rα/IL-1R5 Protein | Adenosylmethionine

Name:
IL-18Rα/IL-1R5 Protein

Synonyms:
CD218a, CD218a, CDw218a, IL18R1, IL18RA, IL-18Ralpha, IL-18R-alpha, IL18Ralpha2, IL1RRP, IL-1Rrp, Interleukin-18 receptor 1, IL-1 R5, IL-1 Rrp, IL-18 R alpha, IL-18 R1, IL18R alpha, IL18R1, IL-18Ra

Species Name:
Human

Label Name:
His Tag

Marker Name:
Unconjugated

Accession:
Q13478

Gene Id:
Cys22-Arg329CTSRPHITVVEGEPFYLKHCSCSLAHEIETTTKSWYKSSGSQEHVELNPRSSSRIALHDCVLEFWPVELNDTGSYFFQMKNYTQKWKLNVIRRNKHSCFTERQVTSKIVEVKKFFQITCENSYYQTLVNSTSLYKNCKKLLLENNKNPTIKKNAEFEDQGYYSCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNVRLNCSALLNEEDVIYWMFGEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLNVLYNCTVASTGGTDTKSFILVRKADMADIPGHVFTRGGGSHHHHHHHH

Molecular Weight:
53-72kDa (Reducing)

Purity:
＞95% by SDS-PAGE &＞95% by SEC-HPLC

Physical Appearance Name:
Lyophilized Powder

Endotoxin Name:
<0.1EU/μg

Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.

Buffer System:
PBS, 5% trehalose, pH7.4

Quality Statement:
Interleukin 18 (IL-18) is a member of the IL-1 family of cytokines and shares numerous immuno-regulatory functions with IL-12. The functional IL-18 receptor complex is composed of two subunits designated IL-18 R alpha (also termed IL-1 R5 and IL-1 Rrp) and IL-18 R beta (also termed IL-1 R7 and AcPL). Both IL-18 R alpha and IL-18 R beta belong to the IL-1 receptor superfamily. IL-18 R is widely expressed in numerous tissues including spleen, thymus, leukocyte, liver, lung, heart, small and large intestine, prostate and placenta. Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B. Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells. Contributes to IL18-induced cytokine production, either. independently of SLC12A3, or as a complex with SLC12A3.

Reference:
1.Parnet, P. et al. (1996) J. Biol. Chem. 271:3967.

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Author: Adenosylmethionine- apoptosisinducer

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