6xHis-ZnF-UBP
Usp5 (IsoT) is a deubiquitinase enzyme that hydrolyzes free polyubiquitin chains. The Usp5 contains two zinc finger domains (ZnF-UBP). This product contains the second ZnF-UBP domain (amino acid 163 – 291). The ZnF-UBP domains bind free ubiquitin chains’ diglycine carboxyl tail, which defines its specificity in binding of free polyubiquitin chains.
Product Name:
6xHis-ZnF-UBP
>Also Known As:
N/A
>Catalog No.:
I1410
>Size:
100 µg
>Molecular Weight:
14.6 kDa
>Species:
Human
>Source:
Bacterial recombinant
>Stock:
20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol
>Concentration:
See tube label
>Quality Assurance:
~80% by SDS-PAGE
>Storage:
Store at -80°C; avoid multiple freeze-thaw cycles
>PDF Data Sheet:
PDF Datasheet， MSDS
>NCBI RefSeq:
N/A
>Image(s):
Images:
(Click image to enlarge)
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Coomassie-stained SDS-PAGE Lane 1: Molecular weight markers Lane 2: 5 µg purified 6xHis-ZnF-UBP |
>Shipping Method:
Dry ice shipping
>References:
1. Hadari T, et al. (1992) J Biol Chem 267, 719 – 727.
2. Reyes-Turcu FE, et al. (2006) Cell 124, 1197 – 1208.
3. Reyes-Turcu FE, et al. (2008) J Biol Chem 283(28), 19581 – 19592.
4. Avvakumov GV, et al. (2012) Biochemistry 51(6), 1188 – 1198. Degarelix 18483217
