Name:
DUSP6 Protein
Synonyms:
Dual specificity protein phosphatase 6, Dual specificity protein phosphatase PYST1, \nMitogen-activated protein kinase phosphatase 3 (MAP kinase phosphatase 3; MKP-3)
Species Name:
Human
Label Name:
His Tag
Marker Name:
Unconjugated
Accession:
Q16828
Gene Id:
Met1-Thr381 HHHHHHHHMIDTLRPVPFASEMAISKTVAWLNEQLELGNERLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRGEDRDRFTRRCGTDTVVLYDESSSDWNENTGGESVLGLLLKKLKDEGCRAFYLEGGFSKFQAEFSLHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDIESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPAQQLYFTTPSNQNVYQVDSLQST
Molecular Weight:
43kDa
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, 2mM TCEP, pH7.4
Quality Statement:
Dual-specific phosphatase-6 (DUSP6), also known as mitogen-activated protein kinase phosphatase-3 (MKP3), has been characterized as a negative feedback regulator of ERK1/2 signaling. It serves a specific and conserved function on the dephosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2). DUSP6 is a cytoplasmic DUSP known to catalyze the removal of phosphate groups from threonine and tyrosine residues on Erk1/2, Which belongs to a family of 25 protein phosphatases that dephosphorylate phosphotyrosine and phosphoserine/phosphothreonine residues within the same substrate.
Reference:
Nat Commun. 2022 Nov 5;13(1):6672. doi: 10.1038/s41467-022-33631-z.Int J Mol Sci. 2023 Apr 22;24(9):7690. doi: 10.3390/ijms24097690.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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