Name:
NT-3 Protein
Synonyms:
HDNF,Nerve growth factor 2,NGF-2,Neurotrophic factor,NTF3
Species Name:
Human
Label Name:
No Tag
Marker Name:
Unconjugated
Accession:
P20783
Gene Id:
Tyr139-Thr257YAEHKSHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEARPVKNGCRGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT
Molecular Weight:
15kDa (Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
20mM Tris, 500mM NaCl, pH8.0
Quality Statement:
Neurotrophin-3 (NT-3) belongs to a family of growth factors called neurotrophins whose actions are centered in the nervous system. The neurotrophin family includes nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), Neurotrophin-3 (NT-3), neurotrophin-4/5 (NT-4/5), neurotrophin-6(NT-6) and the recently cloned neurotrophin-7 Most of biological effects of neurotrophins are mediated by high affinity tyrosine kinase (Trk) receptors, although some of them require the binding to a low affini tyreceptor (p75LNTR). NGF binds to TrkA receptors, BDNF preferentially activates TrkB receptors, while NT-3 mainly interacts with TrkC receptors, and at lower affinity with TrkB receptors.NT-3 is structurally related to other neurotrophins like brain-derived neurotrophic factor. The expression of NT-3 starts with the onset of neurogenesis and continues throughout life. A wealth of information links NT-3 to the growth, differentiation, and survival of hippocampal cells as well as sympathetic and sensory neurons.
Reference:
1.\tElizabeth Hernández-Echeagaray (2020) Vitam Hor. 114:71-89. 2.\tF Marmigère. (2001) Neuroendocrinology 74(1):43-54.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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