Name:
IL-36Rα Protein
Synonyms:
FIL1 delta, IL-1 delta, IL-1F5, IL-1HY1, IL-1L1, IL-1RP3
Species Name:
Human
Label Name:
No Tag
Marker Name:
Unconjugated
Accession:
Q9UBH0
Gene Id:
Val2-Asp155 VLSGALCFRMKDSALKVLYLHNNQLLAGGLHAGKVIKGEEISVVPNRWLDASLSPVILGVQGGSQCLSCGVGQEPTLTLEPVNIMELYLGAKESKSFTFYRRDMGLTSSFESAAYPGWFLCTVPEADQPVRLTQLPENGGWNAPITDFYFQQCD
Molecular Weight:
13kDa (Reducing)
Purity:
＞95% by SDS-PAGE&RP-HPLC
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
20mM Tris, 300mM NaCl, pH8.0
Quality Statement:
The IL-36 family belongs to a larger IL-1 superfamily and consists of three agonists (IL-36α/β/γ), one antagonist (IL-36Ra), one cognate receptor (IL-36R) and one accessory protein (IL-1RAcP). The receptor activation follows a two-step mechanism in that the agonist first binds to IL-36R and the resulting binary complex recruits IL-1RAcP. Assembled ternary complex brings together intracellular TIR domains of receptors which activate downstream NF-κB and MAPK signaling. Antagonist IL-36Ra inhibits the signaling by binding to IL-36R and preventing recruitment of IL-1RAcP.
Reference:
1.\tLi Zhou. (2021) Adv Exp Med Biol. 21:191-210.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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