Name:
RNase H Protein
Synonyms:
Ribonuclease HI、RNase HI、Ribonuclease H、RNase H
Species Name:
null
Label Name:
His Tag
Marker Name:
Unconjugated
Accession:
Gene Id:
/
Molecular Weight:
19 kD
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Liquid
Endotoxin Name:
null
Reconstitution:
/
Stability Storage:
Store at -25 ~ -15℃ for 2 years
Buffer System:
50 mM KCl、10 mM Tris-HCl、0.1 mM EDTA、1 mM DTT、200 µg/ml BSA\n50% Glycerol（pH 7.4 @ 25°C）
Quality Statement:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. RNase H participates in DNA replication; it helps to specify the origin of genomic replication by suppressing initiation at origins other than the oriC locus; along with the 5′-3′ exonuclease of pol1, it removes RNA primers from the Okazaki fragments of lagging strand synthesis; and it defines the origin of replication for ColE1-type plasmids by specific cleavage of an RNA preprimer. Involved in production of retron derived msDNA (a branched RNA linked by a 2′,5′-phosphodiester bond to a single-stranded DNA).
Reference:
[1] Chan S H , Whipple J M , Dai N ,et al.RNase H-based analysis of synthetic mRNA 5′ cap incorporation[J].RNA (New York, N.Y.), 2022, 28(8):1144-1155.DOI:10.1261/rna.079173.122.[2] Ilina T V , Brosenitsch T , Sluis-Cremer N ,et al.Retroviral RNase H: Structure, mechanism, and inhibition[J]. 2021. DOI:10.1016/bs.enz.2021.07.007.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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