Name:
Lokivetmab Protein
Synonyms:
Cytopoint
Species Name:
Canine
Label Name:
null
Marker Name:
Unconjugated
Accession:
Gene Id:
Molecular Weight:
25-27 kDa (Light Chain) & 53-55 kDa (Heavy Chain) (Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4.
Quality Statement:
Lokivetmab is a caninized anti-IL-31 mAb that binds and neutralizes canine IL-31, resulting in reduced skin lesions and inhibition of pruritus in dogs with AD or allergic dermatitis. Lokivetmab is the first mAb approved for use in dogs with canine AD and allergic dermatitis by regulatory agencies worldwide. Lokivetmab targets canine IL-31 specifically and does not bind to murine or human IL-31 or to any other canine proteins. After s.c. administration, lokivetmab is absorbed and incorporated into the pool of circulating antibodies. The long terminal elimination half-life of lokivetmab in dogs of 16.5 ± 3.0 days is due to recycling via the FcRn receptor and allows for monthly injections to maintain efficacy. Elimination by catabolism is identical to any endogenous protein. Lokivetmab binds at a single epitope on canine IL-31, forming a mAb:IL-31 complex having pharmacokinetics and elimination like unbound lokivetmab.
Reference:
1. Matthew Krautmann. Laboratory safety evaluation of lokivetmab, a canine anti-interleukin-31 monoclonal antibody, in dogs. Vet Immunol Immunopathol. 2023 Apr:258:110574. doi: 10.1016/j.vetimm.2023.110574.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
Popular product recommendations:
HGF ProteinSpecies
PD-1 ProteinPurity & Documentation
Popular categories:
Integrin alpha V beta 3
GLP-1
