Name:
Biotinylated B7-H4 Protein
Synonyms:
B7-H4, VTCN1, B7S1, B7h.5
Species Name:
Human
Label Name:
null
Marker Name:
null
Accession:
Q7Z7D3-1
Gene Id:
Phe29-Ala258FGISGRHSITVTTVASAGNIGEDGILSCTFEPDIKLSDIVIQWLKEGVLGLVHEFKEGKDELSEQDEMFRGRTAVFADQVIVGNASLRLKNVQLTDAGTYKCYIITSKGKGNANLEYKTGAFSMPEVNVDYNASSETLRCEAPRWFPQPTVVWASQVDQGANFSEVSNTSFELNSENVTMKVVSVLYNVTINNTYSCMIENDIAKATGDIKVTESEIKRRSHLQLLNSKAGGGSGLNDIFEAQKIEWHEHHHHHHHH
Molecular Weight:
43-60kDa (Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4.
Quality Statement:
V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1/B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.
Reference:
1. Yuping Sun, Yunshan Wang, Jianqiang Zhao, Ming Gu, Ricardo Giscombe, Ann Kari Lefvert a, Xiongbiao Wang: B7-H3 and B7-H4 expression in non-small-cell lung cancer, Lung CancerVolume 53, Issue 2, August 2006, Pages 143-151.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
Popular product recommendations:
PDGF-BB Proteinweb
IL-1 beta ProteinBiological Activity
Popular categories:
Nectin-3
Integrin alpha 10 beta 1
