Name:
PSGL-1/CD162 Protein
Synonyms:
Selectin P ligand, P-selectin glycoprotein ligand 1, PSGL-1, CD162
Species Name:
Human
Label Name:
His Tag
Marker Name:
Unconjugated
Accession:
Q14242-1
Gene Id:
Gln42-Cys320QATEYEYLDYDFLPETEPPEMLRNSTDTTPLTGPGTPESTTVEPAARRSTGLDAGGAVTELTTELANMGNLSTDSAAMEIQTTQPAATEAQTTQPVPTEAQTTPLAATEAQTTRLTATEAQTTPLAATEAQTTPPAATEAQTTQPTGLEAQTTAPAAMEAQTTAPAAMEAQTTPPAAMEAQTTQTTAMEAQTTAPEATEAQTTQPTATEAQTTPLAAMEALSTEPSATEALSMEPTTKRGLFIPFSVSSVTHKGIPMAASNLSVNYPVGAPDHISVKQCGGGSHHHHHHHH
Molecular Weight:
64-93kDa (Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4.
Quality Statement:
PSGL-1, a major selectin ligand on leukocytes, binds P-selectin, E-selectin, and L-selectin under flow conditions. PSGL-1 is a sialomucin of 120 kD that forms disulfide-linked (C320) homodimers. These have two subunits each contain two to three N-glycans, which are critical for P-selectin binding. Each subunit consists of an extracellular, transmembrane, and cytoplasmic domain. PSGL-1 is expressed on most peripheral T cells and on some B cells, neutrophils, monocytes, and platelets. PSGL-1 requires N-terminal tyrosine sulfation for high-affinity P-selectin binding. The PSGL-1 cytoplasmic domain binds ERM proteins, thereby linking PSGL-1 to the actin cytoskeleton. Recently, PSGL-1 has been shown to be of key importance for the delivery of tissue factor to sites of thrombosis. Blocking functional PSGL-1 reduces visceral adipose inflammation and ameliorates endothelial dysfunction in atherosclerosis.
Reference:
Ye Z, Zhong L, Zhu S, Wang Y, Zheng J, Wang S, Zhang J, Huang R. The P-selectin and PSGL-1 axis accelerates atherosclerosis via activation of dendritic cells by the TLR4 signaling pathway. Cell Death Dis. 2019; 10:507.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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