Name:
CD300e/LMIR6 Protein
Synonyms:
CD300LE, CLM2, CMRF35A5, IREM2
Species Name:
Human
Label Name:
Human Fc Tag
Marker Name:
Unconjugated
Accession:
Q496F6
Gene Id:
Leu18-Leu169LKGPGSVTGTAGDSLTVWCQYESMYKGYNKYWCRGQYDTSCESIVETKGEEKVERNGRVSIRDHPEALAFTVTMQNLNEDDAGSYWCKIQTVWVLDSWSRDPSDLVRVYVSPAITTPRRTTHPATPPIFLVVNPGRNLSTGEVLTQNSGFRLGGGSGGGSPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
Molecular Weight:
55-72kDa (Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4.
Quality Statement:
CD300e, originally termed immune receptor expressed by myeloid cells (IREM)-2, is a glycosylated surface receptor with a single extracellular Ig-like domain, belonging to a family of immune receptors that includes 8 members, either activating or inhibitory, that are expressed on myeloid cells, on lymphoid cells or on both compartments1. Since the ligand of CD300e is still unknown, its function in human cells has been studied by using an agonistic anti-CD300e monoclonal antibody2. The evidence that the engagement of CD300e in human monocytes and myeloid dendritic cells provided the cells with survival signals and triggered the expression of the activation markers and the release of pro-inflammatory cytokines, led to the conclusion that CD300e is an immune-activating receptor2. The presence of a lysine residue in the transmembrane domain suggested that CD300e might associate with an ITAM-containing adaptor molecule.
Reference:
1. Sara Coletta,Ambra Bertocco.The immune receptor CD300e negatively regulates T cell activation by impairing the STAT1-dependent antigen presentation. Sci Rep. 2020 Oct 5;10(1):16501. doi: 10.1038/s41598-020-73552-9.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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