Name:
NAP-2/CXCL7 Protein
Synonyms:
PPBP, B-TG1, Beta-TG, CTAP-III, CTAP3, CTAPIII, CXCL-7, LA-PF4, LDGF, MDGF, NAP2, PBP, SCYB7, TC1, TC2, TGB, TGB1, THBGB, THBGB1, pro-platelet basic protein
Species Name:
Human
Label Name:
No Tag
Marker Name:
Unconjugated
Accession:
P02775
Gene Id:
Ala59-Asp128 AELRCMCIKTTSGIHPKNIQSLEVIGKGTHCNQVEVIATLKDGRKICLDPDAPRIKKIVQKKLAGDESAD
Molecular Weight:
9kDa (Reducing)
Purity:
>95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
·12 months from date of receipt, -20 to-70 °C as supplied. ·1 month, 2 to 8 °C under sterileconditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
20mM Tris, 300mM NaCl, pH8.0
Quality Statement:
Neutrophil Activating Peptide 2 (NAP-2), also known as CXCL7, is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. Recently, it has been shown that CXCL7 is secreted by tumor infiltrating monocytes, to stimulate cancer cell migration, invasion, and metastasis, contributing to the promotion of breast cancer progression. It also stimulates the formation and secretion of plasminogen activator by synovial cells. The protein also is an antimicrobial protein with bactericidal and antifungal activity.
Reference:
Wang YH, Shen CY, Lin SC, Kuo WH, Kuo YT, HsuYL, Wang WC, Lin KT, Wang LH. Monocytes secrete CXCL7 to promote breast cancerprogression. Cell Death Dis. 2021 Nov 17;12(12):1090. doi:10.1038/s41419-021-04231-4. PMID: 34789744; PMCID: PMC8599470.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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