Name:
CNTF Protein
Synonyms:
Ciliary neurotrophic factor
Species Name:
Rat
Label Name:
No Tag
Marker Name:
Unconjugated
Accession:
P20294
Gene Id:
Ala2-Met200AFAEQSPLTLHRRDLCSRSIWLARKIRSDLTALMESYVKHQGLNKNISLDSVDGVPVASTDRWSEMTEAERLQENLQAYRTFQGMLTKLLEDQRVHFTPTEGDFHQAIHTLTLQVSAFAYQLEELMALLEQKVPEKEADGMPVTIGDGGLFEKKLWGLKVLQELSQWTVRSIHDLRVISSHHMGISAHESHYGAKQM
Molecular Weight:
22kDa (Reducing)
Purity:
＞95% by SDS-PAGE&RP HPLC
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
20mM PB, 2mM TCEP, pH 7.5
Quality Statement:
Ciliary neurotrophic factor (CNTF) is a pluripotent neurotrophic factor originally isolated from chick embryo ciliary neurons. CNTF has potent effects on the development and maintenance of the nervous system, inducing neuronal survival and differentiation by stimulating gene expression of sensory, sympathetic and motor neurons. Ciliary neurotrophic factor (CNTF) is the most extensively studied member of the cytokine family that signal through intracellular chains of the gp130/LIFRβ receptor. A large body of evidence demonstrates that CNTF promotes rod photoreceptor survival in almost all animal models. Recent studies indicate that CNTF also promotes cone photoreceptor survival and cone outer segment regeneration in the degenerating retina and improves cone function in dogs with congenital achromotopsia.
Reference:
1.\tProg Retin Eye Res. 2012 Mar;31(2):136-51. doi: 10.1016/j.preteyeres.2011.11.005. Epub 2011 Dec 10.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
Popular product recommendations:
GRO-beta/CXCL2 Proteinsite
IL-18 ProteinFormulation
Popular categories:
ADAMTS14
Retinoic Acid Receptor-related Orphan Receptors
