Name:
Biotinylated Fc γ RI/CD64 Protein
Species Name:
Mouse
Label Name:
Avi Tag, His Tag
Marker Name:
Unconjugated
Accession:
P26151
Gene Id:
Glu 25-Pro 297EVVNATKAVITLQPPWVSIFQKENVTLWCEGPHLPGDSSTQWFINGTAVQISTPSYSIPEASFQDSGEYRCQIGSSMPSDPVQLQIHNDWLLLQASRRVLTEGEPLALRCHGWKNKLVYNVVFYRNGKSFQFSSDSEVAILKTNLSHSGIYHCSGTGRHRYTSAGVSITVKELFTTPVLRASVSSPFPEGSLVTLNCETNLLLQRPGLQLHFSFYVGSKILEYRNTSSEYHIARAEREDAGFYWCEVATEDSSVLKRSPELELQVLGPQSSAPGGGSGGGSHHHHHHHHHHGLNDIFEAQKIEWHE
Molecular Weight:
43-53kDa (Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4.
Quality Statement:
Fc γ RI, also known as CD64, is an integral cell membrane glycoprotein that transmits activation signals through the associated Fc R γ chain, commonly referred to as Fc-γ receptor 1 (Fc γ RI), and the high affinity recognition of IgG by Fc γ RI allows it to trigger effector responses at lower low IgG concentrations in early immune responses. After binding to IgG, CD64 interacts with an accessory chain called the common gamma chain, which has an ITAM motif necessary for triggering the cell and for activation. It is usually constitutively expressed on monocytes and macrophages, and can be induced by neutrophils and eosinophils, where its expression is upregulated in bacterial infections and sepsis.
Reference:
1. Joan Cid, Reyes Aguinaco, Rafael Sánchez, Graciano García-Pardo, Andreu Llorente: Neutrophil CD64 expression as marker of bacterial infection: A systematic review and meta-analysis. Journal of Infection, Volume 60, Issue 5, May 2010, Pages 313-319.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
Popular product recommendations:
CRELD1 ProteinBiological Activity
CEACAM8/CD66b ProteinSynonyms
Popular categories:
Hydrolases (EC 3)
Peptide Hormone & Neuropeptides
