Share this post on:

Name:
LAIR1/CD305 Protein

Synonyms:
Immunoglobulin Heavy Chain Variable Region,HLAIR1,LAIR1,Leukocyte Associated Immunoglobulin Like Receptor 1,CD305 Antigen,hLAIR1,CD305,Leukocyte-Associated Ig-Like Receptor 1

Species Name:
Rhesus macaque

Label Name:
Human Fc Tag

Marker Name:
Unconjugated

Accession:
A0A0U3SBU1

Gene Id:
Gln 22-Try165QEGPLPRPSISAEPGTVIPPGRPVTIVCRGPAGVDQFRLEREGRSKFNDTKDVSQASPSESEARFRIDSVSEGNTRHYRCLYRKSTEWSQRSDYLDLVVKETSGDTDSPVTEPDSSAGPTQRPSDNSHNEHAPASQGLSAEHLYGGGSGGGSPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK

Molecular Weight:
50-60kDa (Reducing)

Purity:
>95% by SDS-PAGE

Physical Appearance Name:
Lyophilized Powder

Endotoxin Name:
<0.1EU/μg

Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.

Buffer System:
PBS, pH7.4.

Quality Statement:
LAIR1 (leukocyte-associated Ig-like receptor-1, designated CD305) is an approximately 40 kDa type I transmembrane inhibitory glycoprotein belonging to the Ig superfamily. Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is a type I glycoprotein of 287 amino acids containing a single extracellular Ig-like domain followed by a stalk region connected to the single transmembrane domain and 2 cytoplasmic immunoreceptor tyrosine-based inhibitory motifs that relay the inhibitory signal. LAIR-1 is expressed on almost all immune cells, including NK cells, T cells, B cells and mono-cytes, monocyte-derived dendritic cells, eosinophils, and basophils and mast cells. LAIR-1 binds both transmembrane and extracellular matrix collagens. The mLAIR-1 gene maps to the proximal end of mouse chromosome 7 in a region syntenic with human chromosome 19q13.4 where the LRC is located. LAIR-1 are involved in controlling the balance of the immune system to prevent improper activation or overactivation, which may result in tissue damage or autoimmune diseases. LAIR1 has been shown to inhibit T and NK cell activation mediated by several activating receptors. Furthermore, it has been shown that LAIR1 can deliver an inhibiting signal on intracellular free calcium concentration and immunoglobulin (Ig) production induced by the engagement of B cell antigen receptors (BCR).

Reference:
1.Meyaard, L. (2008) J. Leukoc. Biol. 83:799.2.Meyaard, L. et al. (1997) Immunity 7:283.3.Lebbink, R.J. et al. (2004) J. Immunol. 172:5535.4.Ouyang, W. et al. (2003) Biochem. Biophys. Res. Commun. 310:1236.

MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
Popular product recommendations:
EphB3 Protein
PGLYRP4/PGRP-I beta Protein
Popular categories:
CD2
IL-11

Share this post on:

Author: Adenosylmethionine- apoptosisinducer