AT-406 (SM-406)
AT-406 (also called SM-406) is a potent Smac mimetic that inhibits the ubiquitin ligase activity of inhibitors of apoptosis proteins XIAP, cIAP1 and cIAP2 with Ki values of 66.4, 1.9 and 5.1 nM, respectively. AT-406 induces apoptosis of various human cancer cell lines.
Product Name:
AT-406 (SM-406)
>Also Known As:
CAS# 1071992-99-8
>Catalog No.:
F7170-5
>Size:
5 mg
>Molecular Weight:
561.71 Da
>Species:
N/A
>Source:
Synthetic
>Stock:
Powder
>Concentration:
N/A
>Quality Assurance:
>98% by HPLC and NMR
>Storage:
Eligible for room temperature shipping. Store at -80°C upon receiving; avoid multiple freeze-thaw cycles after dissolving in DMSO.
>PDF Data Sheet:
Download PDF datasheet
>NCBI RefSeq:
N/A
>Image(s):
No
>Shipping Method:
Room temperature shipping
>References:
1. Cai Q., et al. (2011) J. Med. Chem. 54, 2714
2. Brunckhorst M. K., et al. (2012) Cancer Biol. Ther., 13, 804
McMMAF 18481550
