Name:
Eotaxin/CCL11 Protein
Synonyms:
C-C motif chemokine 11, Eosinophil chemotactic protein, Small-inducible cytokine A11
Species Name:
Human
Label Name:
No Tag
Marker Name:
Unconjugated
Accession:
P51671
Gene Id:
Gly24-Pro97GPASVPTTCCFNLANRKIPLQRLESYRRITSGKCPQKAVIFKTKLAKDICADPKKKWVQDSMKYLDQKSPTPKP
Molecular Weight:
10kDa (Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4.
Quality Statement:
Eotaxin/CCL11, produced by eosinophils, B-cells, fibroblasts, endothelial cells, macrophages, chondrocytes and other cells, is a member of the eotaxin family that is chemotactic agents for eosinophils and participate in innate immunity. It is induced by T helper-2 cytokines, like IL-13, IL-10 and IL-4, then transported from the blood to the brain through the Blood-Brain Barrier (BBB).Eotaxin/CCL11 may exert physiological and pathological functions in the central nerve system, and may induce neuronal cytotoxicity effects by inducing the production of reactive oxygen species (ROS) in microglia cells. Plasma levels of CCL11 elevated in neuroinflammation and neurodegenerative disorders.
Reference:
Acta Neurol Belg. 2022; 122(4): 865–869.Pharmaceuticals (Basel). 2020 Sep; 13(9): 230.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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