Name:
USP14 Protein
Synonyms:
Ubiquitin carboxyl-terminal hydrolase 14,Deubiquitinating enzyme 14,Ubiquitin thioesterase 14,Ubiquitin-specific-processing protease 14
Species Name:
Human
Label Name:
His Tag
Marker Name:
Unconjugated
Accession:
P54578
Gene Id:
Q96-Q494 end
Molecular Weight:
47.6 KDa
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Liquid
Endotoxin Name:
<0.01EU/μg
Reconstitution:
Stability Storage:
Stable for up to twelve months from date of receipt at -80℃.
Buffer System:
50 mM Tris-HCl (pH 7.5), 250 mM NaCl, 5% glycerol.
Quality Statement:
Ubiquitin-specific protease 14 (USP14), a deubiquitinating enzyme (DUB), is associated with proteasomes and exerts a dual function in regulating protein degradation. USP14 protects protein substrates from degradation by removing ubiquitin chains from proteasome-bound substrates, whereas promotes protein degradation by activating the proteasome. Increasing evidence have shown that USP14 is involved in several canonical signaling pathways, correlating with cancer, neurodegenerative diseases, autophagy, immune responses, and viral infections. The activity of USP14 is tightly regulated to ensure its function in various cellular processes. Due to its intriguing roles in the stabilization of disease-causing proteins and oncology targets,USP14 has garnered widespread interest as a therapeutic target.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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