Necrostatin-1
Necrostatin-1 is a potent inhibitor of necroptosis, a programmed and caspase-independent cell death mechanism. The death domain receptor-associated serine/threonine kinase RIP1 is essential for TNF-induced necrosis. Necrostatin-1 inhibits RIP1 and blocks TNFα-induced necrosis of FADD-deficient Jurkat cells with an EC50 value of 490 nM.
Product Name:
Necrostatin-1
>Also Known As:
No
>Catalog No.:
F7100
>Size:
5 mg
>Molecular Weight:
259.33 Da
>Species:
N/A
>Source:
Synthetic
>Stock:
Powder
>Concentration:
N/A
>Quality Assurance:
>98% by HPLC and NMR
>Storage:
Eligible for room temperature shipping. Store at -80°C upon receiving; avoid multiple freeze-thaw cycles after dissolving in DMSO.
>PDF Data Sheet:
Download PDF datasheet
>NCBI RefSeq:
N/A
>Image(s):
(Click image to enlarge)
Purity check of Necrostatin-1 by HPLC
>Shipping Method:
Room temperature shipping
>References:
Degterev A, et al. (2008) Nat Chem Biol. 4(5):313-21. Calcitriol 18481079
