Name:
AGER Protein
Synonyms:
RAGE, Receptor for advanced glycosylation end products
Species Name:
Human
Label Name:
His Tag
Marker Name:
Unconjugated
Accession:
Q15109
Gene Id:
Ala23-Ala344, with C-terminal 8*HisAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALAGGGSHHHHHHHH
Molecular Weight:
47-54kDa
Purity:
>95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
12 months from date of receipt, -20 to -70 °C as supplied; 6 months, -20 to -70 °C under sterile conditions after reconstitution; 1 week, 2 to 8 °C under sterile conditions after reconstitution; Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4
Quality Statement:
AGER (advanced glycation end-product-specific receptor encodes a cell surface receptor for advanced glycation end-products (RAGE). This gene is located on the short arm of chromosome 6: 6p21.3. This locus is involved in inflammatory and immune responses and is also the locus of major histocompatibility complex III. Recently, sRAGE was demonstrated as a new biomarker for lung cancer and RAGE could be a potential therapeutic target in Alzheimer’s disease. The genetic background of RAGE demonstrated that some gene polymorphisms are implicated in various pathological states, for example, diabetes complications, amplification of the inflammatory response, non-small cell lung cancer, gastric cancer, or breast cancer.
Reference:
1.Vissing H., Aagaard L., Tommerup N., Boel E.Localization of the human gene for advanced glycosylation end product-specificreceptor (AGER) to chromosome 6p21.3. Genomics. 1994;24(3):606–608. doi:10.1006/geno.1994.1676.2.Yan S. D., Chen X., Fu J., et al. RAGE and amyloid-β peptideneurotoxicity in Alzheimer’s disease. Nature. 1996;382(6593):685–691. doi:10.1038/382685a0.3.Deane R., du Yan S., Submamaryan R. K., et al. RAGE mediates amyloid-βpeptide transport across the blood-brain barrier and accumulation in brain.Nature Medicine. 2003;9(7):907–913. doi: 10.1038/nm890. 4.Krechler T., Jáchymová M., Mestek O., Žák A., Zima T., Kalousová M.Soluble receptor for advanced glycation end-products (sRAGE) and polymorphismsof RAGE and glyoxalase I genes in patients with pancreas cancer. ClinicalBiochemistry. 2010;43(10-11):882–886. doi: 10.1016/j.clinbiochem.2010.04.004.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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