Name:
BTLA Protein
Synonyms:
CD272
Species Name:
Mouse
Label Name:
His Tag
Marker Name:
Unconjugated
Accession:
Q32MV9
Gene Id:
Glu30-Gly176, with C-terminal 10*His EKATKRNDEECEVQLNIKRNSKHSAWTGELFKIECPVKYCVHRPNVTWCKHNGTIWVPLEVGPQLYTSWEENRSVPVFVLHFKPIHLSDNGSYSCSTNFNSQVINSHSVTIHVRERTQNSSEHPLIISDIPDATNASGPSTMEKRPGgggsgggsHHHHHHHHHH
Molecular Weight:
30-45kDa
Purity:
>95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
12 months from date of receipt, -20 to -70 °C as supplied; 6 months, -20 to -70 °C under sterile conditions after reconstitution; 1 week, 2 to 8 °C under sterile conditions after reconstitution; Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4
Quality Statement:
B-and T-lymphocyte attenuator (BTLA) is also known as B-and T-lymphocyte-associated protein, CD antigen CD272. BTLA is a inhibitory molecule which belongs to the Ig superfamily that attenuates BCR and TCR-mediated signaling, and thereby functions as a negative regulator of lymphocyte activation. BTLA contains one Ig-like V-type (immunoglobulin-like) domain. As a lymphocyte inhibitory receptor, BTLA / CD272 inhibits lymphocytes during immune response. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T(H)1) but not T(H)2 cells.
Reference:
1.\tDDEL RIO ML, KAYE J, RODRIGUEZ BARBOSA JI. Detection of protein on BTLAlow cells and in vivo antibody-mediated down-modulation of BTLA on lymphoid and myeloid cells of C57BL/6 and BALB/c BTLA allelic variants.[J]. Immunobiology: Zeitschrift fur Immunitatsforschung, 2010 ,215(7):570-578.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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