Name:
AGER Protein
Synonyms:
RAGE
Species Name:
Mouse
Label Name:
His Tag
Marker Name:
Unconjugated
Accession:
Q62151
Gene Id:
Gly23-Ala342, with C-terminal 8*HisGQNITARIGEPLVLSCKGAPKKPPQQLEWKLNTGRTEAWKVLSPQGGPWDSVARILPNGSLLLPATGIVDEGTFRCRATNRRGKEVKSNYRVRVYQIPGKPEIVDPASELTASVPNKVGTCVSEGSYPAGTLSWHLDGKLLIPDGKETLVKEETRRHPETGLFTLRSELTVIPTQGGTHPTFSCSFSLGLPRRRPLNTAPIQLRVREPGPPEGIQLLVEPEGGIVAPGGTVTLTCAISAQPPPQVHWIKDGAPLPLAPSPVLLLPEVGHEDEGTYSCVATHPSHGPQESPPVSIRVTETGDEGPAEGSVGESGLGTLALAGGGSHHHHHHHH
Molecular Weight:
43-48kDa
Purity:
>95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
12 months from date of receipt, -20 to -70 °C as supplied; 6 months, -20 to -70 °C under sterile conditions after reconstitution; 1 week, 2 to 8 °C under sterile conditions after reconstitution; Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4
Quality Statement:
RAGE(Receptor for Advanced glycosylation End Products) is a 35kD transmembrane receptor of the immunoglobulin superfamily. It is also called AGER. Its name comes from its ability to bind advanced glycation endproducts (AGE), which include chiefly glycoproteins the glycans of which have been modified non-enzymatically through the Maillard reaction. RAGE represents an important factor in innate immunity against pathogens, but it also interacts with endogenous ligands, resulting in chronic inflammation. Studies have demonstrated the role of RAGE in inflammatory cell recruitment and leukocyte extravasation across the endothelial barrier.
Reference:
1．\tReview Invest Clin . 2010 Jun;51(2):257-68.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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