ONC201 (TIC10)
ONC201 (also called TIC10) is a potent TRAIL inducer by inhibition of ERK and AKT. ONC201 promotes nuclear localization of Foxo3a, which then enhances TRAIL transcription to induce cancer cell death. ONC201 is orally active.
Product Name:
ONC201 (TIC10)
>Also Known As:
CAS# 41276-02-2
>Catalog No.:
F6165-5
>Size:
5 mg
>Molecular Weight:
386.49 Da
>Species:
N/A
>Source:
Synthetic
>Stock:
Powder
>Concentration:
N/A
>Quality Assurance:
>98% by HPLC and NMR
>Storage:
Eligible for room temperature shipping. Store at -80°C upon receiving; avoid multiple freeze-thaw cycles after dissolving in DMSO.
>PDF Data Sheet:
Download PDF datasheet
>NCBI RefSeq:
N/A
>Image(s):
No
>Shipping Method:
Room temperature shipping
>References:
1. Allen J E, et al. (2013) Sci. Transl. Med., 5, 171ra17
2. Kline C, et al. (2016) Sci. Signal ., 9, 18r
KB-R7943 (mesylate) 1848046
