Name:
CD45R0 Protein
Species Name:
Human
Label Name:
His Tag
Marker Name:
Unconjugated
Accession:
P08575-4
Gene Id:
Gln26-Lys416, with C-terminal 10*His QSPTPSPTDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKGGGSGGGSHHHHHHHHHH
Molecular Weight:
85-100kDa
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
12 months from date of receipt, -20 to -70 °C as supplied; 6 months, -20 to -70 °C under sterile conditions after reconstitution; 1 week, 2 to 8 °C under sterile conditions after reconstitution; Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4
Quality Statement:
CD45R0 (UCHLI), a member of leucocyte common antigen family, is expressed largely on previously previously activated or memory T cells. The leucocyte common antigen, protein tyrosine phosphatase receptor type C (PTPRC), also known as CD45, is a transmembrane glycoprotein, expressed on almost all haematopoietic cells except for mature erythrocytes, and is an essential regulator of T and B cell antigen receptor-mediated activation. Disruption of the equilibrium between protein tyrosine kinase and phosphatase activity (from CD45 and others) can result in immunodeficiency, autoimmunity, or malignancy. CD45 is normally present on the cell surface, therefore it works upstream of a large signalling network which differs between cell types, and thus the effects of CD45 on these cells are also different. However, it is becoming clear that CD45 plays an essential role in the innate immune system and this is likely to be a key area for future research.
Reference:
1.\tT Miyawaki. Expression of CD45R0 (UCHL1) by CD4+ and CD8+ T cells as a sign of in vivo activation in infectious mononucleosis. Clin Exp Immunol.1991 Mar;83(3):447-51. doi: 10.1111/j.1365-2249. 1991.tb05659. x.2.\tMaryam Ahmed Al Barashdi. Protein tyrosine phosphatase receptor type C (PTPRC or CD45). J Clin Pathol. 2021 Sep;74(9):548-552. doi: 10.1136/jclinpath-2020-206927. Epub 2021 May 26.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
Popular product recommendations:
Gastrin-71 Protein
UBE2H Protein
Popular categories:
Cathepsin C
Tyrosine-protein Kinase YES
