Name:
IFN-α4/IFNA4 Protein
Synonyms:
IFNA4, IFN alpha 4, IFN-alpha 4, IFN-alpha-4, IFN-alpha4a, INFA4, interferon alpha-4, Interferon alpha-4B, Interferon alpha-76, Interferon alpha-M1, interferon, alpha 4, MGC142200
Species Name:
Human
Label Name:
His Tag
Marker Name:
Unconjugated
Accession:
P05014
Gene Id:
Cys24-Asp189, with C-terminal 8*HisCDLPQTHSLGNRRALILLAQMGRISHFSCLKDRHDFGFPEEEFDGHQFQKAQAISVLHEMIQQTFNLFSTEDSSAAWEQSLLEKFSTELYQQLNDLEACVIQEVGVEETPLMNEDSILAVRKYFQRITLYLTEKKYSPCAWEVVRAEIMRSLSFSTNLQKRLRRKDGGGSHHHHHHHH
Molecular Weight:
17-25kDa
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
12 months from date of receipt, -20 to -70 °C as supplied; 6 months, -20 to -70 °C under sterile conditions after reconstitution; 1 week, 2 to 8 °C under sterile conditions after reconstitution; Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4
Quality Statement:
The interferons (IFN) are a family of cytokines with potent antiviral, antiproliferative and immunomodulatory properties, and are classified based on their binding specificity to cell surface receptors. The type I IFNs bind to the interferon alpha receptor (IFNAR), which consists of two subunits: IFNAR1 (alpha-subunit) and IFNAR2 (beta-subunit). This binding contributes to TNF-alpha induced signaling. IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively. Interferon alpha (IFNa) shows significant biological activity in various cancers, particularly haematological malignancies such as hairy cell leukaemia and chronic myelogenous leukaemia. IFN-alpha 4 is promoted by interferon (IFN) regulatory factors (IRFs), especially IRF-1 and IRF-7. And it exhibits function by inhibiting virus RNA replication and enhances human natural killer cytotoxicity against virus.
Reference:
1.\tPestka S, et al. (1987) Annu Rev Biochem. 56:727. 2.\tFung, K.Y. et al. (2013) Science 339:1088. 3.\tMatsumiya, T. et al. (2007) J. Immunol. 179:4542. 4.\tRaj NB, et al. Identification of a novel virus-responsive sequence in the promoter of murine interferon-alpha genes. J Biol Chem. 1991 Jun 15, 266(17):11360-5.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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