Name:
OSMR/IL-31RB Protein
Synonyms:
IL-31R subunit beta, IL-31R-beta, OSMRB
Species Name:
Mouse
Label Name:
His Tag
Marker Name:
Unconjugated
Accession:
O70458
Gene Id:
Glu24-Met737, with C-terminal 10*HisEVLEEPLPLTPEIHKVSFQLKLQEVNLEWTVPALTHEELNMIFQIEISRLNISNTIWVENYSTTVKREEAVRWNWTSDIPLECVKHFIRIRALVDDTKSLPQSSWGNWSSWKEVNAKVSVEPDKSLIFPKDKVLEEGSNVTICLMYGQNVYNVSCKLQDEPIHGEQLDSHVSLLKLNNVVFLSDTGTNINCQATKGPKRIFGTVLFVSKVLEEPKNVSCETRDFKTLDCSWEPGVDTTLTWRKQRFQNYTLCESFSKRCEVSNYRNSYTWQITEGSQEMYNFTLTAENQLRKRSVNINFNLTHRVHPKAPQDVTLKIIGATKANMTWKVHSHGNNYTLLCQVKLQYGEVIHEHNVSVHMSANYLFSDLDPDTKYKAFVRCASANHFWKWSDWTQKEFSTPETAPSQALDVWRQVWSENGRRIVTLFWKPLLKSQANGKIISYNIVVENEAKPTESEHYCVWAPALSTNLSLDLQPYKIRITTNNSMGASPESLMVLSNDSGHEEVKEKTIKGIKDAFNISWEPVSGDTMGYVVDWCAHSQDQRCDLQWKNLGPNTTSTTITSDDFKPGVRYNFRIFERSVEHKARLVEKQRGYTQELAPLVNPKVEIPYSTPNSFVLRWPDYDSDFQAGFIKGYLVYVKSKEMQCNQPWERTLLPDNSVLCKYDINGSETKTLTVENLQPESLYEFFVTPYTSAGPGPNETFTKVTTPDARSHMGGGSGGGSHHHHHHHHHH
Molecular Weight:
110-135kDa (Reducing)
Purity:
>95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
12 months from date of receipt, -20 to -70 °C as supplied; 6 months, -20 to -70 °C under sterile conditions after reconstitution; 1 week, 2 to 8 °C under sterile conditions after reconstitution; Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4
Quality Statement:
Oncostatin M receptor (OSMR), also named as IL‐31R‐β, is a cytokine receptor gene of IL‐6 family and transduces oncostatin M (OSM) and IL‐31 signaling. A recent study shows that OSMR expression is elevated in GBM, especially mesenchymal subtype. OSM/OSMR signaling has been shown to play an important role in driving the glioma cells towards mesenchymal type, and correlated with poor survival. Moreover, OSMR is a direct transcriptional target gene of STAT3 and forms a physical complex with epidermal growth factor receptor vIII (EGFRvIII), a truncated EGFR in which exons 2−7 are deleted. OSMR also promotes the proliferation of human brain tumor stem cells (BTSCs) and the depletion of OSMR impaired EGFRvIII‐STAT3 signaling. Additionally, OSMR may be a key factor and related to JAK/STAT signaling in mediating the effect of endogenous bornavirus‐like nucleoprotein elements on the proliferation and apoptosis of oligodendroglia cells.
Reference:
1.Qing Guo, Ge‐fei Guan, Jing‐yuan Cao, Cun‐yi Zou, Chen Zhu, Wen Cheng. Overexpression of oncostatin M receptor regulates local immune response in glioblastoma. OR IGINAL RESEARCH ARTICLE.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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