TWEAKR/TNFRSF12A Protein | Adenosylmethionine

Name:
TWEAKR/TNFRSF12A Protein

Synonyms:
TNFRSF12A,FGF-inducible 14,FN14,TweakR,CD266

Species Name:
Human

Label Name:
Human Fc Tag

Marker Name:
Unconjugated

Accession:
Q9NP84

Gene Id:
Glu28-Trp79,with N-terminal Human IgG FcPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKIEGREQAPGTAPCSRGSSWSADLDKCMDCASCRARPHSDFCLGCAAAPPAPFRLLW

Molecular Weight:
33-35kDa (Reducing)

Purity:
＞95% by SDS-PAGE

Physical Appearance Name:
Lyophilized Powder

Endotoxin Name:
<0.1EU/μg

Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.

Buffer System:
PBS, pH7.4

Quality Statement:
TNFRSF12A wasinitially identified as a fibroblast growth factor-1-inducible gene in murineNIH 3T3 cells, and was named as fibroblast growth factor-inducible-14 (Fn14)gene. Human TNFRSF12A was cloned froma HUVEC cDNA library and identified as the TWEAK receptor and a member of theTNFR family. TNFRSF12A is highly expressed in heart, placenta and kidney.TNFRSF12A / FN14 promotes angiogenesis and the proliferation of endothelialcells. TNFRSF12A and its ligand play a key role in muscle atrophy, cerebralischemia, kidney injury, atherosclerosis, experimental autoimmune encephalitis,rheumatoid arthritis, and inflammatory bowel disease.

Reference:
1.Feng, S. et al. (2000) Am J. Pathol.156:1253.

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Author: Adenosylmethionine- apoptosisinducer

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