TSLPR Protein | Adenosylmethionine

Name:
TSLPR Protein

Synonyms:
CRLF2, CRL2, ILXR, TSLPR

Species Name:
Human

Label Name:
His Tag

Marker Name:
Unconjugated

Accession:
Q9HC73

Gene Id:
Gln23-Lys231, with C-terminal 8* HisQGGAAEGVQIQIIYFNLETVQVTWNASKYSRTNLTFHYRFNGDEAYDQCTNYLLQEGHTSGCLLDAEQRDDILYFSIRNGTHPVFTASRWMVYYLKPSSPKHVRFSWHQDAVTVTCSDLSYGDLLYEVQYRSPFDTEWQSKQENTCNVTIEGLDAEKCYSFWVRVKAMEDVYGPDTYPSDWSEVTCWQRGEIRDACAETPTPPKPKLSKGGGSHHHHHHHH

Molecular Weight:
33-43kDa (Reducing)

Purity:
＞95% by SDS-PAGE

Physical Appearance Name:
Lyophilized Powder

Endotoxin Name:
<0.1EU/μg

Reconstitution:
Reconstituteat 0.1-1 mg/ml according to the size in ultrapure water after rapidcentrifugation.

Stability Storage:
· 12months from date of receipt, -20 to -70 °C as supplied. · 6months, -20 to -70 °C under sterile conditions after reconstitution.· 1week, 2 to 8 °C under sterile conditions after reconstitution.· Pleaseavoid repeated freeze-thaw cycles.

Buffer System:
PBS, pH7.4

Quality Statement:
TheTSLP receptor (TSLPR, CRLM-2), a typical heterodimeric cytokine receptorconsisting of a TSLP binding subunit (TSLPRα) and the α-subunit of the IL-7receptor (IL-7Rα). TSLPR mRNA has been detected on many immune cell types,including dendritic cells (DCs), T cells, B cells, mast cells, NKT cells andmonocytes as well as in tissues from heart, skeletal muscle, kidney and liver.TSLPR has low affinity for TSLP, but in combination with IL-7Rα generates ahigh affinity binding site for TSLP and triggers signaling. The TSLPR regulatestarget gene expression via the JAK/STAT signalling pathway with participationof signal transducers and activators of transcription STAT3, STAT5 and STAT1.Genetic, experimental, and clinical evidence suggests that the TSLP-TSLPRpathway is associated with the pathogenesis of allergic diseases such as atopicdermatitis (AD) and asthma.

Reference:
1.L S Park. Cloning of the murine thymic stromallymphopoietin (TSLP) receptor: Formation of a functional heteromeric complexrequires interleukin 7 receptor. J Exp Med. 2000 Sep 4;192(5):659-70.

MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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Author: Adenosylmethionine- apoptosisinducer

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