Name:
TrkA/NTRK1 Protein
Synonyms:
MTC, TRK, TRKA
Species Name:
Human
Label Name:
His Tag
Marker Name:
Unconjugated
Accession:
P04629
Gene Id:
Ala33-Gly423, with C-terminal 8*His AAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGGGGSHHHHHHHH
Molecular Weight:
72-90kDa (Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.\n
Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4
Quality Statement:
The tyrosine kinase receptor TrkA (orneurotrophin receptor kinase 1, NTRK1) has been predominately studied for itsrole during the development of the nervous system. In developing neurons, TrkAactivation upon binding of its ligands nerve growth factor (NGF) orneurotrophin-3(NT-3) results in the stimulation of various tyrosinekinase-induced signaling pathways leading to neuronal outgrowth. In the adult,where neurogenesis is largely reduced, TrkA acts as a pain receptor in sensoryneurons and contributes to the transmission of pain signals to the centralnervous system. Interestingly, TrkA is also oncogenic and there is accumulatingevidence for its overexpression and involvement in cancer progression ,including in the form of TrkA fusion proteins as described in lung cancer.Furthermore, TrkA is a therapeutic target in oncology and Trk inhibitors are beingtested in several clinical trials.
Reference:
1.Nathan Griffin, Mark Marsland, Severine Roselli. The Receptor Tyrosine Kinase TrkA Is Increasedand Targetable in HER2-Positive Breast Cancer. Biomolecules 2020, 10
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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