Name:
TNFSF11/RANKL Protein
Synonyms:
RANKL,CD254,TRANCE,OPGL,ODF
Species Name:
Human
Label Name:
Human Fc Tag
Marker Name:
Unconjugated
Accession:
O14788-2
Gene Id:
Gly63-Asp244,with N-terminal Human IgG FcPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKIEGRGSQHIRAEKAMVDGSWLDLAKRSKLEAQPFAHLTINATDIPSGSHKVSLSSWYHDRGWAKISNMTFSNGKLIVNQDGFYYLYANICFRHHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKLRSGEEISIEVSNPSLLDPDQDATYFGAFKVRDID
Molecular Weight:
55-60kDa (Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.\n
Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4
Quality Statement:
RANKL (also known asTRANCE or OPGL) is a member of the TNF ligand superfamily. RANKL is produced byT cells, mammary epithelial cells and endothelial cells. RANKL, through its ability to stimulateosteoclast formation and activity, is a critical mediator of bone resorptionand overall bone density. RANK and RANKL are key regulators of bone remodelingand regulate T cell/dendritic cell communications, and lymph node formation.RANK-RANKLsignaling not only activates a variety of downstream signaling pathwaysrequired for osteoclast development, but crosstalk with other signalingpathways also fine-tunes bone homeostasis both in normal physiology anddisease.
Reference:
1.O’Brien, C.A. (2010) Bone 46, 911-9.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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