Name:
Nectin-3/CD113 Protein
Synonyms:
CD113 antigen; CD113; CDw113FLJ90624; DKFZp566B0846; nectin 3; Nectin3; Nectin-3; poliovirus receptor-related 3; poliovirus receptor-related protein 3; PPR3; PRR3CD113; PVRL3; PVRR3
Species Name:
Human
Label Name:
His Tag
Marker Name:
Unconjugated
Accession:
Q9NQS3
Gene Id:
Gly58-Asp400, with C-terminal 8*HisGPIIVEPHVTAVWGKNVSLKCLIEVNETITQISWEKIHGKSSQTVAVHHPQYGFSVQGEYQGRVLFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIKGPDSLIDGGNETVAAICIAATGKPVAHIDWEGDLGEMESTTTSFPNETATIISQYKLFPTRFARGRRITCVVKHPALEKDIRYSFILDIQYAPEVSVTGYDGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPDGLLASDNTLHFVHPLTFNYSGVYICKVTNSLGQRSDQKVIYISDPPTTTTLQPTIQWHPSTADIEDLATEPKKLPFPLSTLATIKDDGGGSHHHHHHHH
Molecular Weight:
65-85kDa (Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4
Quality Statement:
Nectins are a smallfamily of Ca++-independent immunoglobulin (Ig)-like cell adhesion molecules(CAMs) that organize intercellular junctions. The Nectin family has at leastfour members (Nectin-1 – 4), all of which show alternate splicing, atransmembrane (TM) region (except for Nectin-1 gamma ), and three extracellularIg-domains. Nectin-3 (also named PRR3, CD113 and PVRL3) is an 83 kDa, type I TMglycoprotein. NECTIN3 is intended to initiate cell-cell adhesion to stimulatecell attachment and to allow subsequent formation of JAM-and cadherin-basedintercellular junctions. NECTIN3 induces endocytosis-mediated down-regulationof PVR from the cell surface, which results in reduction of cell movement &proliferation. Following Nectin-3 activity adds strength to the junctionthrough trans-interaction with various molecules.
Reference:
1.Takai, Y. and H. Nakanishi (2003) J. Cell Sci.116:17.2.Miyoshi, J. and Y. Takai (2007) Am. J. Nephrol.27:590.3.Sakisaka, T. et al. (2007) Curr. Opin. Cell Biol.19:593.4.Rikitake, Y. and Y. Takai (2008) Cell. Mol. LifeSci. 65:253.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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