Name:
LAG-3 GST Tag Protein
Synonyms:
LAG-3,CD223 Antigen, Protein FDC, CD223, FDC, sLAG-3
Species Name:
Human
Label Name:
GST Tag
Marker Name:
Unconjugated
Accession:
P18627
Gene Id:
Leu23-Leu450,with N-terminal GST Tag MSPILGYWKIKGLVQPTRLLLEYLEEKYEEHLYERDEGDKWRNKKFELGLEFPNLPYYIDGDVKLTQSMAIIRYIADKHNMLGGCPKERAEISMLEGAVLDIRYGVSRIAYSKDFETLKVDFLSKLPEMLKMFEDRLCHKTYLNGDHVTHPDFMLYDALDVVLYMDPMCLDAFPKLVCFKKRIEAIPQIDKYLKSSKYIAWPLQGWQATFGGGDHPPKGGGSGGGSDDDDKLQPGAEVPVVWAQEGAPAQLPCSPTIPLQDLSLLRRAGVTWQHQPDSGPPAAAPGHPLAPGPHPAAPSSWGPRPRRYTVLSVGPGGLRSGRLPLQPRVQLDERGRQRGDFSLWLRPARRADAGEYRAAVHLRDRALSCRLRLRLGQASMTASPPGSLRASDWVILNCSFSRPDRPASVHWFRNRGQGRVPVRESPHHHLAESFLFLPQVSPMDSGPWGCILTYRDGFNVSIMYNLTVLGLEPPTPLTVYAGAGSRVGLPCRLPAGVGTRSFLTAKWTPPGGGPDLLVTGDNGDFTLRLEDVSQAQAGTYTCHIHLQEQQLNATVTLAIITVTPKSFGSPGSLGKLLCEVTPVSGQERFVWSSLDTPSQRSFSGPWLEAQEAQLLSQPWQCQLYQGERLLGAAVYFTELSSPGAQRSGRAPGALPAGHL
Molecular Weight:
75-80kDa (Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.\n
Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4
Quality Statement:
LAG3 is a member ofthe immunoglobulin superfamily and a CD4 ancestral homolog, resulting from agene duplication event. Like CD4, LAG3 binds MHC class II (MHCII), but also FGL-1,α-synucleinfibrils (α-syn) and the lectins galectin-3 (Gal-3) and lymph node sinusoidalendothelial cell C-type lectin (LSECtin). As an immune checkpoint, LAG3inhibits the activation of its host cell and generally promotes a moresuppressive immune response. On T cells, LAG3 reduces cytokine and granzymeproduction and proliferation while encouraging differentiation into Tregulatory cells.
Reference:
1.Colin G. Graydon, Shifa Mohideen and Keith R.Fowke, LAG3’s Enigmatic Mechanism of Action. Frontiers in Immunology
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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