Name:
Biotinylated MSLN Protein
Synonyms:
CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor
Species Name:
Human
Label Name:
Human Fc Tag, Avi Tag
Marker Name:
Biotin
Accession:
Q13421-1
Gene Id:
Glu296-Gly580, with C-terminal Human IgG1 Fc &Avi tagEVEKTACPSGKKAREIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLDVLKHKLDELYPQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQAPRRPLPQVATLIDRFVKGRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDPRQLDVLYPKARLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDAVLPLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGLNDIFEAQKIEWHE
Molecular Weight:
72-85kDa (Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
· 12months from date of receipt, -20 to -70 °C as supplied. · 6months, -20 to -70 °C under sterile conditions after reconstitution.· 1week, 2 to 8 °C under sterile conditions after reconstitution.·Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4
Quality Statement:
Mesothelin, also known as CAK1 and ERC, isderived from a 70 kDa precursor that also includes Megakaryocyte PotentiatingFactor (MPF). The 70 kDa precursor is expressed on the cell surface where it iscleaved at a dibasic proteolytic site to release the 32 kDa glycosylated MPF.MPF is a cytokine that potentiates IL-3 induced megakaryocyte colony formation.The term Mesothelin refers to the 40 kDa glycosylated protein which remainsattached to the cell surface via a GPI linkage. Both MPF and the cleaved formof mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16.The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPFpotentiates megakaryocyte colony formation in vitro.
Reference:
1.Hassan, R. et al: Mesothelin: a new target for immunotherapy, Clin.Cancer Res. 10:3937(2004).
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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