Name:
Biotinylated CTLA4 Protein
Synonyms:
CTLA4,CD152
Species Name:
Human
Label Name:
Human Fc Tag, Avi Tag
Marker Name:
Biotin
Accession:
P16410
Gene Id:
Ala37 – Phe162, withC-terminal Human IgG1Fc & Avi tagAMHVAQPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVIDPEPCPDSDFIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGLNDIFEAQKIEWHE
Molecular Weight:
43-55Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
· 12months from date of receipt, -20 to -70 °C as supplied. · 6months, -20 to -70 °C under sterile conditions after reconstitution.· 1week, 2 to 8 °C under sterile conditions after reconstitution.·Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4
Quality Statement:
Cytotoxic T-lymphocyte-associated protein 4(CTLA-4) is an inhibitory receptor belonging to the CD28 immunoglobulinsubfamily, expressed primarily by T-cells. The family includes CD28, CTLA-4 andICOS as well as other proteins including PD-1, BTLA and TIGIT.Its ligands, CD80and CD86, are typically found on the surface of antigen-presenting cells andcan either bind CD28 or CTLA-4, resulting in a costimulatory or a co-inhibitoryresponse, respectively. Because of its dampening effect, CTLA-4 is a crucial regulatorof T-cell homeostasis and self-tolerance. The mechanisms by which CTLA-4 exertsits inhibitory function can be categorized as either cell-intrinsic (affectsthe CTLA-4 expressing T-cell) or cell-extrinsic (affects secondary cells).CTLA-4 mainly acts in a cell-extrinsic manner via its competition with CD28,CTLA-4-mediated trans-endocytosis of CD80 and CD86, and its direct tolerogeniceffects on the interacting cell.
Reference:
1.Shuang Qin, Linping Xu, Ming Yi, Shengnan Yu,Kongming Wu & Suxia Luo: Novel immune checkpoint targets: moving beyondPD-1 and CTLA-4: MolecularCancer volume 18, Article number: 155 (2019).
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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