Name:
IGF-I Protein
Synonyms:
IGF-I Protein, IGF1A Protein, IGFI Protein
Species Name:
Mouse
Label Name:
No Tag
Marker Name:
Unconjugated
Accession:
P05017
Gene Id:
Gly49-Ala118 GPETLCGAELVDALQFVCGPRGFYFNKPTGYGSSIRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPTKAA
Molecular Weight:
8-9kDa (Non-Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
· 12months from date of receipt, -20 to -70 °C as supplied. · 6months, -20 to -70 °C under sterile conditions after reconstitution.· 1week, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
50mM NaAc, pH6.0.
Quality Statement:
Insulin-like growth factor I (IGF-I) belongs tothe family of Insulin-like growth factors that are structurally homologous toproInsulin. Mature IGFs are generated by proteolytic processing of inactiveprecursor protein containing N-terminal and C-terminal propeptide regions.IGF-1 is produced primarily by the liver as an endocrine hormone as well as intarget tissues in a paracrine/autocrine fashion. The production of IGF-1 isstimulated by growth hormone (GH) and can be retarded by undernutrition, growthhormone insensitivity, lack of growth hormone receptors, or failures of thedownstream signaling pathway post GH receptor including SHP2 and STAT5B. IGF1binds IGF-1R, IGF-2R, and the Insulin receptor and plays a key role in cellcycle progression, cell proliferation and tumor progression.
Reference:
1.Bartlett WP,Li XS, Williams M. 1992. Brain Res Mol Brain Res, 12: 285-91.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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