Name:
Thrombomodulin Protein
Synonyms:
TM
Species Name:
Human
Label Name:
His Tag
Marker Name:
Unconjugated
Accession:
P07204
Gene Id:
Ala19-Ser515, with C-terminal 8* HisAPAEPQPGGSQCVEHDCFALYPGPATFLNASQICDGLRGHLMTVRSSVAADVISLLLNGDGGVGRRRLWIGLQLPPGCGDPKRLGPLRGFQWVTGDNNTSYSRWARLDLNGAPLCGPLCVAVSAAEATVPSEPIWEEQQCEVKADGFLCEFHFPATCRPLAVEPGAAAAAVSITYGTPFAARGADFQALPVGSSAAVAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEPSPCPQRCVNTQGGFECHCYPNYDLVDGECVEPVDPCFRANCEYQCQPLNQTSYLCVCAEGFAPIPHEPHRCQMFCNQTACPADCDPNTQASCECPEGYILDDGFICTDIDECENGGFCSGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDGGDSGSGEPPPSPTPGSTLTPPAVGLVHSGGGSHHHHHHHH
Molecular Weight:
72-83 kDa (Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
· 12months from date of receipt, -20 to -70 °C as supplied. · 6months, -20 to -70 °C under sterile conditions after reconstitution.· 1week, 2 to 8 °C under sterile conditions after reconstitution.·Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4
Quality Statement:
Thrombomodulin (TM) is a transmembrane glycoprotein located on theluminal surface of endothelial cells in most normal blood vessels thatregulates coagulation and inflammation. Encoded by an intronless gene on chromosome 20, the mature single-chainTM glycoprotein in the human is 557 amino acids long, structurally organizedinto five distinct regions, including the cytoplasmic and transmembranedomains, a serine/threonine-rich region with an attached chondroitin sulfatemoiety, six consecutive EGF-like repeats, and the N-terminal lectin-likedomain. Thrombomodulin is an endothelial cell thrombin receptor that convertsthrombin into an anticoagulant capable of activating protein C, suggesting aprotective role in thrombosis. TM may also affect astrocyte function andprotect against thrombin-induced neuronal cell death via an APC-dependentmechanism.
Reference:
1.Pindon A, Hantai D, Jandrot-Perrus M, Festoff BW.Novel expression and localization of active thrombomodulin on the surface ofmouse brain astrocytes. Glia 1997; 19: 259– 68.2.Shibata M, Kumar SR, Amar A, Fernandez JA, Hofman F, Griffin JH, ZlokovicBV. Anti-inflammatory, antithrombotic, and neuroprotective effects of activatedprotein C in a murine model of focal ischemic stroke. Circulation 2001; 103:1799– 805.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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