SerpinC1/Antithrombin III Protein

Name:
SerpinC1/Antithrombin III Protein

Synonyms:
AT3, ATIII

Species Name:
Human

Label Name:
His Tag

Marker Name:
Unconjugated

Accession:
P01008

Gene Id:
His33-Lys464, with C-terminal 8*His HGSPVDICTAKPRDIPMNPMCIYRSPEKKATEDEGSEQKIPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCVKGGGSHHHHHHHH

Molecular Weight:
55-72kDa (Reducing)

Purity:
＞95% by SDS-PAGE

Physical Appearance Name:
Lyophilized Powder

Endotoxin Name:
<0.1EU/μg

Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability Storage:
· 12months from date of receipt, -20 to -70 °C as supplied. · 6months, -20 to -70 °C under sterile conditions after reconstitution.· 1week, 2 to 8 °C under sterile conditions after reconstitution.·Please avoid repeated freeze-thaw cycles.

Buffer System:
PBS, pH7.4

Quality Statement:
The gene SerpinC1 encodes a serine protease inhibitornamed Antithrombin III (ATIII).This protease demonstrates both anticoagulantand anti-inflammatory action. ATIII is the most important coagulation factorinhibitor, and even minor changes in ATIII can significantly alter the risk ofthromboembolism. ATIII can also suppress inflammation via a coagulation-dependentor -independent effect. Moreover, apart from ATIII deficiency, ATIIIand its gene SerpinC1may also be related to many diseases (e.g. hypertension, kidney diseases). Thepresent review summarizes how ATIII affects the progress of kidney disease and itsmechanism.

Reference:
1.Zeyuan Lu. Feng Wang. SerpinC1/Antithrombin III in kidney-relateddiseases. Clinical Science (2017) 131 823–831

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Author: Adenosylmethionine- apoptosisinducer

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