Name:
IL-6R alpha/CD126 Protein
Synonyms:
IL-6 receptor subunit alpha, IL-6R subunit alpha, IL-6R-alpha, IL-6RA
Species Name:
Human
Label Name:
Human Fc Tag
Marker Name:
Unconjugated
Accession:
P08887
Gene Id:
Leu20 – Pro365, with C-terminal Human IgG1 FcLAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSANATSLPVQDSSSVPLPIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
Molecular Weight:
76-93 kDa (Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
· 12months from date of receipt, -20 to -70 °C as supplied. · 6months, -20 to -70 °C under sterile conditions after reconstitution.· 1week, 2 to 8 °C under sterile conditions after reconstitution.·Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4
Quality Statement:
TheInterleukin-6 receptor (IL-6R) consists of an 80-kDa IL-6 binding protein (αchain) (CD126) and gp130. The alpha-chain CD126 is a glycoprotein that containsthe ligand-binding site. The human IL-6R protein contains 468 amino acids,which includes a signal peptide, an extracellular region, a transmembranedomain, and a short cytoplasmic domain of 19, 339, 28, and 82 amino acids,respectively. IL-6R are present on several types of tumor cells, includingmultiple myeloma, hepatocellular carcinoma, prostate carcinoma , and epidermoidcarcinoma. The IL-6/IL-6R signal pathway promotes the tumor growth in variouscancers, especially for glioma. Hence, IL-6R not only can be used as a targetsite for transporting drugs, but also as a therapeutic site. Primary humancartilage cells express IL-6R, which is further induced in the presence ofIL-6. This makes cartilage cells direct targets or effectors of IL-6.
Reference:
1.M Hibi, M Murakami, M Saito, T Hirano, T Taga, TKishimoto. Molecular cloning and expression of an IL-6 signal transducer,gp130.Cell. 1990 Dec 21;63(6):1149-57. doi: 10.1016/0092-8674(90)90411-7.2. Bin S, Xin L, Lin Z, Jinhua Z, Rui G, Xiang Z.Targeting miR-10a-5p/IL-6Raxis for reducing IL-6-induced cartilage cell ferroptosis.Exp Mol Pathol. 2021Feb;118:104570. Cell., 63 (1990), pp. 1149-1157.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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