Name:
FGF-6 Protein
Synonyms:
HST2, HBGF-6
Species Name:
Human
Label Name:
No Tag
Marker Name:
Unconjugated
Accession:
P10767
Gene Id:
Gly41-Ile208 MGTRANNTLLDSRGWGTLLSRSRAGLAGEIAGVNWESGYLVGIKRQRRLYCNVGIGFHLQVLPDGRISGTHEENPYSLLEISTVERGVVSLFGVRSALFVAMNSKGRLYATPSFQEECKFRETLLPNNYNAYESDLYQGTYIALSKYGRVKRGSKVSPIMTVTHFLPRI
Molecular Weight:
16~19kDa (Reducing)
Purity:
＞95% by SDS-PAGE & RP-HPLC
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
20mM Tris, 300mM NaCl, pH8.0
Quality Statement:
Fibroblast GrowthFactor-6 (FGF-6) is a cytokine belonging to the heparin-binding member of theFGF family. Members of this family possess broad mitogenic and cell survival activities,and are involved in a variety of biological processes, including embryonicdevelopment, cell growth, morphogenesis, tissue repair, tumor growth andinvasion. FGF-6 binds and signals through the FGF receptors: FGFR1 and FGFR4.It is also required for normal muscle regeneration. In vivo high concentrationof recombinant FGF-6 up-regulates and down-regulates FGFR1 and FGFR4,respectively, as FGFR1 promotes the proliferation while FGFR4 promotes thedifferentiation in the muscle. FGF6 gene displayed oncogenic transformingactivity when transfected into mammalian cells. Despite the function in muscleprotection against mechanical damage, FGF6 overexpresses in developmental heartand regulates osteoblasts and osteoclasts for bone remodeling.
Reference:
1.Hu Z, Chen P, Wang L, Zhu Y, Chen G, Chen Y, HuZ, Mei L, You W, Cong W, Jin L, Wang X, Wang Y, Guan X. FGF6 promotes cardiacrepair after myocardial infarction by inhibiting the Hippo pathway. CellProlif. 2022 May;55(5):e13221. doi: 10.1111/cpr.13221. Epub 2022 Mar 30. PMID:35355356; PMCID: PMC9136516.2. Bosetti M, Leigheb M, Brooks RA, Boccafoschi F, Cannas MF. Regulation ofosteoblast and osteoclast functions by FGF-6. J Cell Physiol. 2010Nov;225(2):466-71. doi: 10.1002/jcp.22225. PMID: 20458746.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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