IL-2R alpha/CD25 Protein

Quality Statement:
Interleukin-2 receptor subunit alpha (IL2RA) is also known as IL-2R subunit alpha, IL-2-RA, IL2-RA, TAC antigen, p55, CD antigen CD25, is a type I transmembrane glycoprotein. The interaction of interleukin-2 (IL-2) with its receptor (IL-2R) critically regulates the T-cell immune response, and the α chain CD25/IL-2Rα is required for the formation of the high-affinity receptor. Among them, IL-2 plays a major role in the regulation of the magnitude and duration of T-cell activation in the immune responses. IL-2 promotes T-cell proliferation by interacting with its high-affinity receptor composed of three transmembrane polypeptides, the α, β, and γc chains. The α chain (CD25) is induced during T-cell activation, and its association with β and γc chains constitutes the high-affinity receptor. Most of the biologic effects of IL-2 are mediated through the high-affinity complex as evidenced by the almost identical phenotype of mice with targeted inactivation of the genes for IL-2 and IL-2Rα.

Reference:
1、Nelson B H. et al. (1998) Biology of the interleukin-2 receptor. Adv Immunol. 70: 1-81.2、Schorle H. et al. (1991) Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature. 352: 621-624.3、Willerford D M. et al. (1995) Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity. 3: 521-530.