Name:
ICAM-1/CD54 Protein
Synonyms:
BB2, CD54 antigen, CD54, cell surface glycoprotein P3.58, human rhinovirus receptor, ICAM1, ICAM-1, intercellular adhesion molecule 1 (CD54)
Species Name:
Human
Label Name:
Human Fc Tag
Marker Name:
Unconjugated
Accession:
Gene Id:
Gln28-Glu480, with C-terminal Human IgG1 FcQTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGIETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAPLPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLVRRDHHGANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLDGLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILGNQSQETLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQLLLKATPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQAWGNPLPELKCLKDGTFPLPIGESVTVTRDLEGTYLCRARSTQGEVTRKVTVNVLSPRYEIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
Molecular Weight:
49-72kDa (Reducing)
Purity:
>95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution.1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4
Quality Statement:
ICAM-1 is a cell-surface glycoprotein and a member of the immunoglobulin (Ig) protein superfamily. ICAM-1 mediates the interaction between keratinocytes and leukocytes. ICAM-1 facilitates a variety of both afferent and efferent immune responses that require intercellular contact and collaboration, including T helper responses, T-dependent B cell responses, antigen-induced T cell proliferation, cell-mediated cytotoxicity, and the binding of leukocytes to vascular endothelium prior to extravasation into inflamed tissue. Pro-inflammatory cytokines interferon-γ and TNF-α stimulate the expression of keratinocyte ICAM-1 and this up-regulation is blocked both in vivo and in vitro if keratinocytes are irradiated with UVB prior to cytokine treatment. In contrast, ICAM-2 is expressed primarily on endothelium and leukocytes (except neutrophils), and its expression generally is not responsive to cytokines. ICAM-3 predominates on thymocytes and resting lymphocytes, which are low in ICAM-1. When neutrophils are activated, they shed the majority of their ICAM-3 into the medium by proteolytic cleavage. In some reports, the expression of ICAM-1 has been positively correlated with a more aggressive tumor phenotype and metastatic potential. For instance, the invasiveness of breast cancer cells has been positively correlated with the expression of ICAM-1. Also, it has been suggested that an ICAM-1–ICAM-1 homophilic interaction between breast cancer cells and mesenchymal stem cells in bone marrow mediates the metastatic expansion of cancer cells, displacing hematopoietic stem cells from their niche.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
Popular product recommendations:
Mesothelin Proteincustom synthesis
GSTA1 Proteinsupplier
Popular categories:
Fc Receptor-like Proteins
MMP-10