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Name:
Galectin-3 Protein

Synonyms:
35 kDa Lectin, Carbohydrate-binding protein 35 (CBP 35), Galactose-specific Lectin 3, Galactoside-binding protein (GALBP)

Species Name:
Human

Label Name:
No Tag

Marker Name:
Unconjugated

Accession:

Gene Id:
Ala2-Ile250, tag freeADNFSLHDALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSATGAYPATGPYGAPAGPLIVPYNLPLPGGVVPRMLITILGTVKPNANRIALDFQRGNDVAFHFNPRFNENNRRVIVCNTKLDNNWGREERQSVFPFESGKPFKIQVLVEPDHFKVAVNDAHLLQYNHRVKKLNEISKLGISGDIDLTSASYTMI

Molecular Weight:
30kDa (Reducing)

Purity:
>95% by SDS-PAGE & RP-HPLC

Physical Appearance Name:
Lyophilized Powder

Endotoxin Name:
<1EU/μg

Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability Storage:
12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution.1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles.

Buffer System:
PBS, pH7.4, 2mM DTT

Quality Statement:
Galectin-3 (Gal-3) is a member of the galectin family of carbohydrate binding proteins which have affinity for beta-galactoside. Gal-3 is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. Gal-3 can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. Gal-3 is expressed in the nucleus, cytoplasm, mitochondrion, cell surface and extracellular space, and plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation and exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants, Gal-3 plays an important role in the pathogenesis of neuroinflammatory and neurodegenerative disorders, such as multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. On the other hand, there is also evidence of the protective role of Gal-3 due to its anti-apoptotic effect in target cells.

MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
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Author: Adenosylmethionine- apoptosisinducer