Product Name :
Bedaquiline fumarate
Description:
Bedaquiline, also known as TMC207 and R207910, is a diarylquinoline anti-tuberculosis drug, which was discovered by a team led by Koen Andries at Janssen Pharmaceutica. Bedaquiline blocks the proton pump for ATP synthase of mycobacteria. ATP production is required for cellular energy production and its loss leads to cell death, even in dormant or nonreplicating mycobacteria.It is the first member of a new class of drugs called the diarylquinolines. Bedaquiline is bactericidal.
CAS:
845533-86-0
Molecular Weight:
671.58
Formula:
C36H35BrN2O6
Chemical Name:
(1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol; (2E)-but-2-enedioic acid
Smiles :
COC1=NC2=CC=C(Br)C=C2C=C1[C@@H](C1C=CC=CC=1)[C@@](O)(CCN(C)C)C1=CC=CC2=CC=CC=C21.OC(=O)/C=C/C(O)=O
InChiKey:
ZLVSPMRFRHMMOY-WWCCMVHESA-N
InChi :
InChI=1S/C32H31BrN2O2.Lurasidone custom synthesis C4H4O4/c1-35(2)19-18-32(36,28-15-9-13-22-10-7-8-14-26(22)28)30(23-11-5-4-6-12-23)27-21-24-20-25(33)16-17-29(24)34-31(27)37-3;5-3(6)1-2-4(7)8/h4-17,20-21,30,36H,18-19H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t30-,32-;/m1./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Bedaquiline, also known as TMC207 and R207910, is a diarylquinoline anti-tuberculosis drug, which was discovered by a team led by Koen Andries at Janssen Pharmaceutica.Alkaline phosphatase custom synthesis Bedaquiline blocks the proton pump for ATP synthase of mycobacteria.PMID:32562109 ATP production is required for cellular energy production and its loss leads to cell death, even in dormant or nonreplicating mycobacteria.It is the first member of a new class of drugs called the diarylquinolines. Bedaquiline is bactericidal.|Product information|CAS Number: 845533-86-0|Molecular Weight: 671.58|Formula: C36H35BrN2O6|Synonym:|R403323|Sirturo fumarate|TMC207 fumarate|R207910 fumarate|Chemical Name: (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol; (2E)-but-2-enedioic acid|Smiles: COC1=NC2=CC=C(Br)C=C2C=C1[C@@H](C1C=CC=CC=1)[C@@](O)(CCN(C)C)C1=CC=CC2=CC=CC=C21.OC(=O)/C=C/C(O)=O|InChiKey: ZLVSPMRFRHMMOY-WWCCMVHESA-N|InChi: InChI=1S/C32H31BrN2O2.C4H4O4/c1-35(2)19-18-32(36,28-15-9-13-22-10-7-8-14-26(22)28)30(23-11-5-4-6-12-23)27-21-24-20-25(33)16-17-29(24)34-31(27)37-3;5-3(6)1-2-4(7)8/h4-17,20-21,30,36H,18-19H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t30-,32-;/m1./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
